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Cocaine Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Cocaine (cocaine hydrochloride topical solution) is used by health care professionals to temporarily numb the lining of the mouth, nose, and throat (mucous membranes) before certain medical procedures (e.g., biopsy, stitches, wound cleaning). It is an anesthetic that works to numb the area. This medication is available in generic form. Common side effects include dizziness, nausea, nervousness, unusual feelings of well-being, or restlessness.
The dosage of Cocaine Hydrochloride Topical Solution varies and depends upon the area to be anesthetized, vascularity of the tissues, individual tolerance, and the technique of anesthesia. Cocaine Hydrochloride Topical Solution can be administered by means of cotton applicators or packs, instilled into a cavity, or as a spray. Cocaine Hydrochloride Topical Solution may interact with MAO inhibitors, stimulant-type drugs, isoniazid, phenothiazines, theophylline, or tricyclic antidepressants. Tell your doctor all medications you are taking. During pregnancy, Cocaine topical should be used only when prescribed. This drug may pass into breast milk and could have undesirable effects on a nursing infant. Breast-feeding is not recommended while using this drug.
Our Cocaine (cocaine hydrochloride topical solution) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Cocaine Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: fever, mental/mood changes (e.g., drowsiness, confusion, hallucinations, mood swings), numbness in application area several hours after procedure, loss of smell or taste, vision problems (e.g., blurred vision, sensitivity to light).
Tell your doctor immediately if any of these rare but very serious side effects occur: slow/shallow/rapid breathing, fainting, fast/slow/irregular/pounding heartbeat, severe headache, shaking (tremors).
Seek immediate medical attention if any of these rare but very serious side effects occur: chest pain, seizures.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Cocaine (Cocaine Hydrochloride Topical Solution)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Cocaine FDA Prescribing Information: Side Effects
Adverse reactions may be due to high plasma levels as a result of excessive and rapid absorption of the drug. Reactions are systemic in nature and involve the central nervous system and/or the cardiovascular system. A small number of reactions may result from hypersensitivity, idiosyncrasy or diminished tolerance on the part of the patient.
CNS reactions are excitatory and/or depressant, and may be characterized by nervousness, restlessness and excitement. Tremors and eventually clonictonic convulsions may result. Emesis may occur. Central stimulation is followed by depression, with death resulting from respiratory failure.
Cocaine (cocaine hydrochloride topical solution) is pyrogenic, augmenting heat production in stimulating muscular activity and causing vasoconstriction which decreases heat loss. Cocaine (cocaine hydrochloride topical solution) is known to interfere with the uptake of norepinephrine by adrenergic nerve terminals, producing sensitization to catecholamines, causing vasoconstriction and mydriasis.
Cocaine (cocaine hydrochloride topical solution) causes sloughing of the corneal epithelium, causing clouding, pitting, and occasionally ulceration of the cornea. The drug is not meant for ophthalmic use.
Read the entire FDA prescribing information for Cocaine (Cocaine Hydrochloride Topical Solution)
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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