Brand Name: Cocaine Topical
Generic Name: cocaine
Drug Class: Anesthetics, Topical; Local Anesthetics, Esters
What Is Cocaine and How Does It Work?
Cocaine naturally occurring chemical found in the leaves of Erythroxylum coca or coca plant. Cocaine is a highly addictive stimulant drug that directly affects the nervous system, including the brain. Risk for addiction is a common problem which prevents widespread clinical use. Powder cocaine (commonly referred to as coke), freebase and crack (crack cocaine) are all forms of the cocaine substance. Cocaine may also be used as a topical anesthetic is indicated for the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.
Cocaine is available under the following different brand names: Cocaine topical.
Dosages of Cocaine Should Be Given As Follows:
Dosage Forms & StrengthsTopical solution: Schedule II
- 4% (pediatric and adult strength)
Dosage Considerations for Topical Anesthesia
As local anesthetic for accessible mucous membranes (oral, nasal and laryngeal)
1-10% solution: Use lowest dose necessary to produce adequate anesthesia.
Do not exceed 3 mg/kg or 300 mg.
Dosage variables include tissue vascularity, anesthetic technique and patient tolerance.
Reduce dose for elderly or debilitated patients.
Administer using cotton applicators or packs, instilled into a cavity, or as a spray.
Apply only on mucous membranes of mouth, laryngeal, or nasal cavities.
The fatal dose of cocaine has been approximated at 1.2 g., although severe toxic effects have been reported from doses as low as 20 mg.
The symptoms of cocaine poisoning are referable to the CNS, namely the patient becomes excited, restless, garrulous, anxious and confused. Enhanced reflexes, headache, rapid pulse, irregular respiration, chills, rise in body temperature, mydriasis, exophthalmos, nausea, vomiting and abdominal pain are noticed. In severe overdoses, delirium, Cheyne-Stokes respiration, convulsions, unconsciousness, and death from respiratory arrest result. Acute poisoning by cocaine develops rapidly in time.
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