November 26, 2015
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Codeine Phosphate

"July 10, 2015 -- Popular painkillers like ibuprofen and naproxen have carried warnings for years about potential risks of heart attacks and strokes. This week, the FDA decided to strengthen those warnings on the medications, known as nonsteroidal"...

Codeine Phosphate


Codeine phosphate is a centrally active analgesic. When administered parenterally, 120 mg of codeine phosphate produces an analgesic response equivalent to that from 10 mg of morphine. Other actions include respiratory depression; depression of the cough center; release of antidiuretic hormone; activation of the vomiting center; pupillary constriction; a decrease in gastric, pancreatic, and biliary secretion; a reduction in intestinal motility; an increase in biliary tract pressure; and an increased amplitude of ureteral contractions.

Onset of analgesia following intramuscular or subcutaneous administration occurs within 10 to 30 minutes. The effect persists for 4 to 6 hours.

Most of a dose of codeine is excreted within 24 hours, 5% to 15% as unchanged codeine and the remainder as a product of glucuronide conjugates of codeine and its metabolites.

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

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