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Codeine Phosphate

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Codeine Phosphate

CLINICAL PHARMACOLOGY

Codeine phosphate is a centrally active analgesic. When administered parenterally, 120 mg of codeine phosphate produces an analgesic response equivalent to that from 10 mg of morphine. Other actions include respiratory depression; depression of the cough center; release of antidiuretic hormone; activation of the vomiting center; pupillary constriction; a decrease in gastric, pancreatic, and biliary secretion; a reduction in intestinal motility; an increase in biliary tract pressure; and an increased amplitude of ureteral contractions.

Onset of analgesia following intramuscular or subcutaneous administration occurs within 10 to 30 minutes. The effect persists for 4 to 6 hours.

Most of a dose of codeine is excreted within 24 hours, 5% to 15% as unchanged codeine and the remainder as a product of glucuronide conjugates of codeine and its metabolites.

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

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