"SAN ANTONIO â€” Patients with severe chronic pain, including those with arachnoiditis, have low serum cortisol levels, a new study has shown.
Before prescribing opioids to such patients, clinicians should check cortisol levels, and if t"...
(codeine sulfate) Tablets
DEATH RELATED TO ULTRA-RAPID METABOLISM OF CODEINE TO MORPHINE
Respiratory depression and death have occurred in children who received codeine following tonsillectomy and/or adenoidectomy and had evidence of being ultra-rapid metabolizers of codeine due to a CYP2D6 polymorphism.
Chemically, codeine is Morphinan-6-ol,7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-(5α,6α)-, sulfate (2:1) (salt), trihydrate. Its empirical formula is C18H21NO3 and its molecular weight is 299.36. Its structure is as follows:
Each tablet contains 15, 30, or 60 mg of codeine sulfate and the following inactive ingredients: colloidal silicon dioxide, microcrystalline cellulose, pregelatinized starch, and stearic acid.
What are the possible side effects of codeine ()?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Seek emergency medical attention if a child taking this medication has any of the following life-threatening side effects: noisy breathing, sighing, slow breathing with long pauses between breaths; being unusually sleepy or hard to wake up; blue colored lips.
Call your doctor at once if you have a serious side effect such as:
- slow heart rate, weak pulse, fainting, shallow breathing;
- feeling like you...
What are the precautions when taking codeine (Codeine Sulfate)?
Before taking codeine, tell your doctor or pharmacist if you are allergic to it; or to other narcotic pain medications (e.g., morphine, hydrocodone, oxycodone); or if you have any other allergies. This product may contain inactive ingredients (such as sulfites found in some brands), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: stomach/abdominal problems (such as blockage, constipation, diarrhea due to infection, paralytic ileus, gallbladder disease, pancreatitis, ulcerative colitis), adrenal gland problems (such as Addison's disease), brain disorders (such as seizures, head injury, tumor), heart problems (such as irregular heartbeat,...
Last reviewed on RxList: 10/17/2016
This monograph has been modified to include the generic and brand name in many instances.
Additional Codeine Sulfate Information
Codeine Sulfate - User Reviews
Codeine Sulfate User Reviews
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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