Coenzyme Q-10

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Coenzyme Q-10 Safety and Side Effects

Coenzyme Q-10 is safe for most adults. While most people tolerate coenzyme Q-10 well, it can cause some mild side effects including stomach upset, loss of appetite, nausea, vomiting, and diarrhea. It can cause allergic skin rashes in some people. It also might lower blood pressure, so check your blood pressure carefully if you have very low blood pressure. Dividing the total daily dose by taking smaller amounts two or three times a day instead of a large amount all at once can help reduce side effects.

Coenzyme Q-10 also seems to be safe for most children. But coenzyme Q-10 should not be used in children without medical supervision.

Do not use coenzyme Q-10 if:

  • You are pregnant or breast-feeding.
  • You are scheduled for surgery in the next two weeks.

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What other names is Coenzyme Q-10 known by?

Co Q10, Co Q-10, Coenzima Q-10, Co-Enzyme 10, Coenzyme Q 10, Coenzyme Q10, Co-Enzyme Q10, Co-Enzyme Q-10, Co-Q 10, CoQ10, Co-Q10, CoQ-10, Ubidcarenone, Ubidécarénone, Ubiquinone-10.

What is Coenzyme Q-10?

Coenzyme Q-10 (CoQ-10) is a vitamin-like substance found throughout the body, but especially in the heart, liver, kidney, and pancreas. It is eaten in small amounts in meats and seafood. Coenzyme Q-10 can also be made in a laboratory. It is used as medicine.

Likely Effective for...

  • Coenzyme Q-10 deficiency (very rare).
  • Mitochondrial disorders, inherited or acquired disorders that limit energy production in the cells of the body.

Possibly Effective for...

  • Congestive heart failure (CHF), in combination with other medications.
  • Decreasing the risk of additional heart problems in people who have had a recent heart attack (myocardial infarction).
  • Huntington's disease.
  • Preventing blood vessel complications caused by heart bypass surgery.
  • High blood pressure (hypertension) in combination with other medications.
  • Preventing migraine headache.
  • Parkinson's disease. Some research shows that taking coenzyme Q-10 supplements might slow functional decline in people with early Parkinson's disease. But taking a coenzyme Q-10 supplement in people with mid-stage Parkinson's disease does not seem to improve symptoms.
  • Improving the immune system of people with HIV/AIDS.
  • Muscular dystrophy, an inherited disorder involving muscle wasting.

Likely Ineffective for...

  • Improving exercise performance.
  • Dental (periodontal) disease, when applied directly to the teeth and gums.

Insufficient Evidence to Rate Effectiveness for...

  • Improving blood sugar control in people with diabetes, breast cancer, fatigue, Lyme disease, male infertility, chest pain (angina), a muscle condition called "statin-induced myopathy," cardiomyopathy in children and adults, and other conditions.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).


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