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Cogentin

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Cogentin

CLINICAL PHARMACOLOGY

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COGENTIN possesses both anticholinergic and antihistaminic effects, although only the former have been established as therapeutically significant in the management of parkinsonism.

In the isolated guinea pig ileum, the anticholinergic activity of this drug is about equal to that of atropine; however, when administered orally to unanesthetized cats, it is only about half as active as atropine.

In laboratory animals, its antihistaminic activity and duration of action approach those of pyrilamine maleate.

Last reviewed on RxList: 5/3/2013
This monograph has been modified to include the generic and brand name in many instances.

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