Colchicine (Colchicine) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Colchicine

Gout »

What is gout? What is hyperuricemia?

Gout is a disease that results from an overload of uric acid in the body. This overload of uric acid leads to the formation of tiny crystals of urate that deposit in tissues of the body, especially the joints. When crystals form in the joints, it causes recurring attacks of joint inflammation (arthritis). Gout is considered a chronic and progressive disease. Chronic gout can also lead to deposits of hard lumps of uric acid in the tissues, particularly in and around the joints and may cause joint destruction, decreased kidney function, and kidney stones (nephrolithiasis).

Gout has the unique distinction of being one of the most frequently recorded medical illnesses throughout history. It is often related to an inherited abnormality in the body's ability to process uric acid. Uric acid is a breakdown product of purines that are part of many foods we eat. An abnormality in handling uric acid can cause attacks of p...

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Colchicine

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DRUG DESCRIPTION

Colchicine is an alkaloid prepared from the dried corns and seeds of Colchicum autumnale, the autumn crocus or meadow saffron. It is a pale yellow powder soluble in water in 1:25 dilution.

Colchicine Tablets, USP are oral anti-inflammatory agents supplied in two dosage strengths 0.5 mg (l/120 gr) and 0.6 mg (l/100 gr). The chemical name for colchicine is (S) N-(5,6,7,9-tetrahydro- 1,2,3, IO-tetramethoxy-9-oxobenzo [alpha] heptaien-7-yl) acetamide.

Inactive Ingredients

0.5 mg tablet: Calcium carbonate, confectioner†s sugar (contains corn starch), D& C Yellow No. 10, dextrin, stearic acid, sucrose and talc.

0.6 mg tablet: Acacia, corn starch, D& C Yellow No. 10, lactose, stearic acid and talc.

What are the precautions when taking colchicine (Colchicine)?

Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, liver problems (such as cirrhosis).

Alcohol can decrease this drug's effectiveness. Limit alcohol while taking this drug.

This medication can affect how well your body absorbs some foods and nutrients (such as vitamin B12). Consult your doctor or pharmacist for more details.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription...

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Last reviewed on RxList: 10/4/2010
This monograph has been modified to include the generic and brand name in many instances.