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Colchicine
What is gout? What is hyperuricemia?
Gout is a disease that results from an overload of uric acid in the body. This overload of uric acid leads to the formation of tiny crystals of urate that deposit in tissues of the body, especially the joints. When crystals form in the joints, it causes recurring attacks of joint inflammation (arthritis). Gout is considered a chronic and progressive disease. Chronic gout can also lead to deposits of hard lumps of uric acid in the tissues, particularly in and around the joints and may cause joint destruction, decreased kidney function, and kidney stones (nephrolithiasis).
Gout has the unique distinction of being one of the most frequently recorded medical illnesses throughout history. It is often related to an inherited abnormality in the body's ability to process uric acid. Uric acid is a breakdown product of purines that are part of many foods we eat. An abnormality in handling uric acid can cause attacks of p...
Colchicine
DRUG DESCRIPTION
Colchicine is an alkaloid prepared from the dried corns and seeds of Colchicum autumnale, the autumn crocus or meadow saffron. It is a pale yellow powder soluble in water in 1:25 dilution.
Colchicine Tablets, USP are oral anti-inflammatory agents supplied in two dosage strengths 0.5 mg (l/120 gr) and 0.6 mg (l/100 gr). The chemical name for colchicine is (S) N-(5,6,7,9-tetrahydro- 1,2,3, IO-tetramethoxy-9-oxobenzo [alpha] heptaien-7-yl) acetamide.
Inactive Ingredients
0.5 mg tablet: Calcium carbonate, confectioner†s sugar (contains corn starch), D& C Yellow No. 10, dextrin, stearic acid, sucrose and talc.
0.6 mg tablet: Acacia, corn starch, D& C Yellow No. 10, lactose, stearic acid and talc.
Last reviewed on RxList: 10/4/2010
This monograph has been modified to include the generic and brand name in many instances.
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