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home > drugs a-z list > colchicine (colchicine) drug center > colchicine (colchicine) drug - side effects and drug interactions
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Colchicine
What is gout? What is hyperuricemia?
Gout is a disease that results from an overload of uric acid in the body. This overload of uric acid leads to the formation of tiny crystals of urate that deposit in tissues of the body, especially the joints. When crystals form in the joints, it causes recurring attacks of joint inflammation (arthritis). Gout is considered a chronic and progressive disease. Chronic gout can also lead to deposits of hard lumps of uric acid in the tissues, particularly in and around the joints and may cause joint destruction, decreased kidney function, and kidney stones (nephrolithiasis).
Gout has the unique distinction of being one of the most frequently recorded medical illnesses throughout history. It is often related to an inherited abnormality in the body's ability to process uric acid. Uric acid is a breakdown product of purines that are part of many foods we eat. An abnormality in handling uric acid can cause attacks of p...
Colchicine
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SIDE EFFECTS
Adverse reactions in decreasing order of severity are: bone marrow depression, with aplastic anemia, with agranulocytosis or with thrombocytopenia may occur in patients receiving long-term therapy. Peripheral neuritis, purpura, myopathy, loss of hair, and reversible azoospermia have also been reported.
Vomiting, diarrhea, and nausea may occur with colchicine therapy, especially when maximal doses are necessary for a therapeutic effect. To avoid more serious toxicity, the drug should be discontinued when these symptoms appear, regardless of whether or not joint pain has been relieved.
Dermatoses have been reported. Hypersensitivity reactions may occur infrequently.
DRUG INTERACTIONS
Colchicine is inhibited by acidifying agents. The action of colchicine is potentiated by alkalinizing agents.
Colchicine may increase sensitivity to the CNS depressants.
Response to sympathomimetic agents' may be enhanced by colchicine.
Last reviewed on RxList: 10/4/2010
This monograph has been modified to include the generic and brand name in many instances.
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