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Colchicine should be administered with caution to aged or debilitated patients, and to those with early manifestations of gastrointestinal, renal, hepatic, cardiac, or hematological disorders. (see CONTRAINDICATIONS).
Colchicine is inhibited by acidifying agents. The action of colchicine is potentiated by alkalinizing agents.
Response to sympathomimetic agentsmay be enhanced by colchicine.
Laboratory Test Interactions
Decreased thrombocyte values may be obtained during colchicine therapy.
WARNINGS section for information on impairment of fertility.
Pregnancy Category C. Colchicine has been shown to be teratogenic in mice when given doses of 1.25 and 1.5 mg/kg and in hamsters when given 10 mg/kg. There are no adequate and well-controlled studies in pregnant women. Colchicine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when colchicine is administered to a nursing woman.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 10/4/2010
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