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In this Article

• What is colchicine (Colcrys)?
• What are the possible side effects of colchicine (Colcrys)?
• What is the most important information I should know about colchicine (Colcrys)?
• What should I discuss with my healthcare provider before taking colchicine (Colcrys)?
• How should I take colchicine (Colcrys)?
• What happens if I miss a dose (Colcrys)?
• What happens if I overdose (Colcrys)?
• What should I avoid while taking colchicine (Colcrys)?
• What other drugs will affect colchicine (Colcrys)?
• Where can I get more information?

What happens if I miss a dose (Colcrys)?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Colcrys)?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of colchicine can be fatal.

Overdose symptoms may include diarrhea (may be bloody and severe), nausea, vomiting, stomach pain, heartburn, a burning feeling in your throat or stomach, muscle weakness, urinating less than usual, numbness or tingling, fainting, or seizure (convulsions).

What should I avoid while taking colchicine (Colcrys)?

Grapefruit and grapefruit juice may interact with colchicine and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

What other drugs will affect colchicine (Colcrys)?

Colchicine can interact with certain other drugs. A colchicine drug interaction can be fatal. Tell your doctor about all other medications you use, especially:

• conivaptan (Vaprisol);
• digoxin (Lanoxin, digitalis);
• diclofenac (Arthrotec, Cataflam, Voltaren, Flector Patch, Solareze);
• imatinib (Gleevec);
• isoniazid (for treating tuberculosis);
• quinidine (Quinaglute, Quinidex, Quin-Release);
• an antidepressant such as nefazodone;
• an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), or telithromycin (Ketek);
• an antifungal medication such as clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);
• cholesterol-lowering medicines such as atorvastatin (Lipitor), fenofibrate (Antara, Lipofen, TriCor), gemfibrozil (Lopid), simvastatin (Zocor), lovastatin (Mevacor), pravastatin (Pravachol), and others;
• heart or blood pressure medication such as amiodarone (Cordarone, Pacerone), diltiazem (Cartia, Cardizem), felodipine (Plendil), nicardipine (Cardene), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others;
• HIV or AIDS medication such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Kaletra, Norvir); or
• medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf).

This list is not complete and there may be other drugs that can interact with colchicine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about colchicine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed

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