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home > drugs a-z list > coly-mycin m (colistimethate injection) drug center > coly-mycin m (colistimethate injection) drug - clinical pharmacology
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Coly-Mycin
Pneumonia facts
- Pneumonia is a lung infection that can be caused by different types of microorganisms, including bacteria, viruses, and fungi.
- Symptoms of pneumonia include cough with sputum production, fever, and sharp chest pain on inspiration (breathing in).
- Pneumonia is suspected when a doctor hears abnormal sounds in the chest, and the diagnosis is confirmed by a chest X-ray.
- Bacteria causing pneumonia can be identified by sputum culture.
- A pleural effusion is a fluid collection around the inflamed lung.
- Bacterial and fungal (but not viral) pneumonia can be treated with antibiotics.
What is pneumonia?
Pneumonia is an infection of one or both lungs which is usually caused by bacteria, viruses, or fungi. Prior to the discovery of antibiotics, one-third of all people who developed pneumonia subsequently died fro...
Coly-Mycin M
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CLINICAL PHARMACOLOGY
Typical serum and urine levels following a single 150 mg dose of Coly-Mycin M (colistimethate injection) Parenteral IM or IV in normal adult subjects are shown in Figure 1.
Figure 1
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Higher serum levels were obtained at 10 minutes following IV administration. Serum concentration declined with a half-life of 2–3 hours following either intravenous or intramuscular administration in adults and in the pediatric population, including premature infants.
Average urine levels ranged from about 270 mcg/mL at 2 hours to about 15 mcg/mL at 8 hours after intravenous administration and from 200 to about 25 mcg/mL during a similar period following intramuscular administration.
Microbiology
Colistimethate sodium is a surface active agent which penetrates into and disrupts the bacterial cell membrane. It has been shown to have bactericidal activity against most strains of the following microorganisms, both in vitro and in clinical infections as described in the INDICATIONS section:
Aerobic gram-negative microorganisms
Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa.
Susceptibility Tests
Colistimethate sodium is no longer listed as an antimicrobial for routine testing and reporting by clinical microbiology laboratories.
Last reviewed on RxList: 7/27/2009
This monograph has been modified to include the generic and brand name in many instances.
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