Coly-Mycin S Otic

Coly-Mycin® S Otic with Neomycin and Hydrocortisone
(colistin sulfate—neomycin sulfate—thonzonium bromide—hydrocortisone acetate) Otic Suspension

Coly-Mycin S Otic

DRUG DESCRIPTION

Coly-Mycin® S Otic with Neomycin and Hydrocortisone (colistin sulfate with neomycin and hydrocortisone ) (colistin sulfate—neomycin sulfate— thonzonium bromide—hydrocortisone acetate otic suspension) is a sterile antibacterial and antiinflammatory aqueous suspension containing in each mL: Colistin base activity, 3 mg (as the sulfate); Neomycin base activity, 3.3 mg (as the sulfate); Hydrocortisone acetate, 10 mg (1%); Thonzonium bromide, 0.5 mg (0.05%); Polysorbate 80, acetic acid, and sodium acetate in a buffered aqueous vehicle. Thimerosal (mercury derivative), 0.002%, is added as a preservative. It is a nonviscous liquid, buffered at pH 5, for instillation into the canal of the external ear or direct application to the affected aural skin.

The structural formulas of colistin sulfate (mixture of Colistin A & B), neomycin sulfate (mixture of neomycin A, B & C), hydrocortisone acetate ((11β)-21-(acetyloxy)-11,17-dihydroxypregn) methyl]-2 pyrimidinylamino] ethyl]-N,N-dimethyl-1 hexadecanaminium, bromide) are represented below:

 Coly-Mycin®S Otic with Neomycin and Hydrocortisone (colistin sulfate—neomycin sulfate—thonzonium bromide—hydrocortisone acetate) Structural Formula Illustration

What are the possible side effects of colistin, hydrocortisone, neomycin, and thonzonium (Coly Mycin S, Coly-Mycin S, Cortisporin-TC)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • skin rash, redness, swelling, itching, dryness, or scaling;
  • hearing loss; or
  • urinating less than usual or not at all.

This is not a complete list of side effects and others may occur. Tell your doctor about any...

Read All Potential Side Effects and See Pictures of Coly-Mycin S Otic »

Last reviewed on RxList: 6/22/2009
This monograph has been modified to include the generic and brand name in many instances.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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