Coly-Mycin® S Otic with Neomycin and Hydrocortisone (colistin sulfate with neomycin and hydrocortisone ) (colistin sulfate—neomycin sulfate— thonzonium bromide—hydrocortisone acetate otic suspension) is a sterile antibacterial and antiinflammatory aqueous suspension containing in each mL: Colistin base activity, 3 mg (as the sulfate); Neomycin base activity, 3.3 mg (as the sulfate); Hydrocortisone acetate, 10 mg (1%); Thonzonium bromide, 0.5 mg (0.05%); Polysorbate 80, acetic acid, and sodium acetate in a buffered aqueous vehicle. Thimerosal (mercury derivative), 0.002%, is added as a preservative. It is a nonviscous liquid, buffered at pH 5, for instillation into the canal of the external ear or direct application to the affected aural skin.

The structural formulas of colistin sulfate (mixture of Colistin A & B), neomycin sulfate (mixture of neomycin A, B & C), hydrocortisone acetate ((11β)-21-(acetyloxy)-11,17-dihydroxypregn) methyl]-2 pyrimidinylamino] ethyl]-N,N-dimethyl-1 hexadecanaminium, bromide) are represented below:

Last reviewed on RxList: 6/22/2009
This monograph has been modified to include the generic and brand name in many instances.