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COMBIGAN® (brimonidine tartrate/timolol maleate) Ophthalmic Solution 0.2%/0.5% is an alpha-adrenergic receptor agonist with a beta-adrenergic receptor inhibitor indicated for the reduction of elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension who require adjunctive or replacement therapy due to inadequately controlled IOP; the IOP-lowering of COMBIGAN® dosed twice a day was slightly less than that seen with the concomitant administration of 0.5% timolol maleate ophthalmic solution dosed twice a day and 0.2% brimonidine tartrate ophthalmic solution dosed three times per day.
DOSAGE AND ADMINISTRATION
The recommended dose is one drop of COMBIGAN® in the affected eye(s) twice daily approximately 12 hours apart. If more than one topical ophthalmic product is to be used, the different products should be instilled at least 5 minutes apart.
Dosage Forms And Strengths
Solution containing 2 mg/mL brimonidine tartrate and 5 mg/mL timolol (6.8 mg/mL timolol maleate).
Storage And Handling
COMBIGAN® is supplied sterile, in white opaque plastic LDPE bottles and tips, with blue high impact polystyrene (HIPS) caps as follows:
5 mL in 10 mL bottle NDC 0023-9211-05
10 mL in 10 mL bottle NDC 0023-9211-10
Store at 15°- 25°C (59°-77°F). Protect from light.
Allergan, Inc., Irvine, CA 92612, U.S.A. Revised: 10/2012
Last reviewed on RxList: 10/19/2012
This monograph has been modified to include the generic and brand name in many instances.
Additional Combigan Information
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