May 31, 2016
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Combivir

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Combivir




Overdosage
Contraindications

OVERDOSE

There is no known specific treatment for overdose with COMBIVIR. If overdose occurs, the patient should be monitored and standard supportive treatment applied as required.

Lamivudine

Because a negligible amount of lamivudine was removed via (4-hour) hemodialysis, continuous ambulatory peritoneal dialysis, and automated peritoneal dialysis, it is not known if continuous hemodialysis would provide clinical benefit in a lamivudine overdose event.

Zidovudine

Acute overdoses of zidovudine have been reported in pediatric patients and adults. These involved exposures up to 50 grams. No specific symptoms or signs have been identified following acute overdosage with zidovudine apart from those listed as adverse events such as fatigue, headache, vomiting, and occasional reports of hematological disturbances. Patients recovered without permanent sequelae. Hemodialysis and peritoneal dialysis appear to have a negligible effect on the removal of zidovudine, while elimination of its primary metabolite, 3'azido-3'-deoxy-5'-O-β-D-glucopyranuronosylthymidine (GZDV), is enhanced.

CONTRAINDICATIONS

COMBIVIR is contraindicated in patients with a previous hypersensitivity reaction to lamivudine or zidovudine.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 10/8/2015

Overdosage
Contraindications

Combivir - User Reviews

Combivir User Reviews

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