Combivir (Lamivudine, Zidovudine) Patient Information: Missed a Dose and What Should I Avoid at RxList

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May 26, 2012

Combivir

HIV and AIDS: Antiretroviral Drugs, Treatments and Medications »

Entry Inhibitors (including Fusion Inhibitors) and CCR5 Co-receptor Antagonist

Entry Inhibitors
Entry inhibitors block HIV entry into CD4+ cells.

Fusion inhibitors
The only drug in this class is T-20, which is administered as a twice daily subcutaneous injection. The most common side effect is redness and pain at the site of injection. Rarely, infection can occur at the injection site. There also are reports of generalized allergic reactions.

CCR5 antagonist
Although there were some early concerns of liver inflammation for drugs in this class, MVC appeared to be well tolerated in clinical trials without any specific toxicities attributable to the drug. However, it is a new drug in a new class and the first to actually target the cell. For these reasons, longer follow-up from clinical trials and those followed in the clinic will be very important for assessing the overall safety of the...

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Combivir Patient Information including If I Miss a Dose

What happens if I miss a dose (Combivir)?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Combivir)?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, vomiting, headache, dizziness, drowsiness, confusion, and seizure (convulsions).

What should I avoid while taking lamivudine and zidovudine (Combivir)?

The combination of lamivudine and zidovudine (Combivir) should not be taken together with any other medications that contain either of these two drugs. This includes Epivir, Retrovir, Epzicom (abacavir and lamivudine), and Trizivir (abacavir, lamivudine, zidovudine).

Avoid contact with people who have colds, the flu, or other contagious illnesses. Contact your doctor immediately if you develop signs of infection.

Avoid having unprotected sex or sharing needles, razors, or toothbrushes. Taking this medication will not prevent you from passing HIV to other people. Talk with your doctor about safe methods of preventing HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What other drugs will affect lamivudine and zidovudine (Combivir)?

Tell your doctor about all other medications you use, especially:

cancer treatments;
stavudine (Zerit);
doxorubicin (Adriamycin);
zalcitabine (Hivid);
ganciclovir (Cytovene);
interferon-alfa (Roferon, Intron, Rebetron);
sulfamethoxazole and trimethoprim (Bactrim, Proloprim, Septra, Trimpex, SMX-TMP); or
ribavirin (Rebetol, Ribasphere, Copegus Virazole).

This list is not complete and there may be other drugs that can interact with lamivudine and zidovudine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about lamivudine and zidovudine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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