Combunox (Oxycodone HCl and Ibuprofen) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Combunox

Pain Management: Musculoskeletal Pain »

What Causes Musculoskeletal Pain?

The causes of musculoskeletal pain are varied. Muscle tissue can be damaged with the wear and tear of daily activities. Trauma to an area (jerking movements, auto accidents, falls, fractures, sprains, dislocations, and direct blows to the muscle) also can cause musculoskeletal pain. Other causes of pain include postural strain, repetitive movements, overuse, and prolonged immobilization. Changes in posture or poor body mechanics may bring about spinal alignment problems and muscle shortening, therefore causing other muscles to be misused and become painful.

What Are the Symptoms of Musculoskeletal Pain?

People with musculoskeletal pain sometimes complain that their entire bodies ache. Their muscles may feel like they have been pulled or overworked. Sometimes the muscles twitch or burn. Symptoms vary from person to person, but the common symptoms are:

Pain
Fatigue
Sl...

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Combunox™
(oxycodone hcl and ibuprofen) Tablets

Cardiovascular Risk

NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk (See WARNINGS).
Combunox™ (oxycodone hcl and ibuprofen) is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).

Gastrointestinal Risk

NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events (See WARNINGS).

DRUG DESCRIPTION

Each combination Combunox™ (oxycodone hcl and ibuprofen) tablet contains:

Oxycodone HCl, USP 5 mg
Ibuprofen, USP 400 mg

Combunox (oxycodone hcl and ibuprofen) is supplied in a fixed combination tablet form for oral administration and combines the opioid analgesic agent, oxycodone HCl, with the nonsteroidal anti-inflammatory (NSAID) agent, ibuprofen.

Oxycodone HCl is a centrally acting semisynthetic opioid analgesic. Its chemical name is 4,5α-Epoxy-14-hydroxy-3-methoxy-methylmorphinan-6-one hydrochloride. Its chemical formula is C₁₈H₂₁NO₄ HCl and molecular weight is 351.83. Its structural formula is:

Oxycodone HCl Structural Formula Illustration

Ibuprofen is a nonsteroidal anti-inflammatory drug with analgesic and antipyretic properties. Its chemical name is (±)-2-(p-isobutylphenyl) propionic acid. Its chemical formula is C₁₃H₁₈O₂ and molecular weight is 206.29. Its structural formula is:

Ibuprofen Structural Formula Illustration

Inactive ingredients in Combunox (oxycodone hcl and ibuprofen) tablets include: sodium starch glycolate, microcrystalline cellulose, colloidal silicon dioxide, stearic acid, calcium stearate, carboxymethylcellulose, povidone, Opadry® II White, Y-22 7719 coloring agent. Opadry® II White, Y-22 7719 coloring agent consists of titanium dioxide, polydextrose, hypromellose, triacetin and polyethylene glycol 8000.

What are the possible side effects of ibuprofen and oxycodone (Combunox)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee ground;
swelling or rapid weight gain;
shallow breathing, slow...

Read All Potential Side Effects and See Pictures of Combunox »

What are the precautions when taking oxycodone hcl and ibuprofen (Combunox)?

Before taking this medication, tell your doctor or pharmacist if you are allergic to oxycodone or ibuprofen; or to other narcotic pain relievers (such as codeine, hydrocodone); or to aspirin or other NSAIDs (such as naproxen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: intestinal/bowel disorders (such as paralytic ileus, infectious diarrhea, colitis, blockage), recent heart bypass surgery (CABG), kidney disease, liver disease, bleeding/blood-clotting disorders (such as hemophilia, vitamin K deficiency, low platelet count),...

Read All Potential Precautions of Combunox »

Last reviewed on RxList: 9/23/2010
This monograph has been modified to include the generic and brand name in many instances.