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In this Article

• What is ibuprofen and oxycodone (Combunox)?
• What are the possible side effects of ibuprofen and oxycodone (Combunox)?
• What is the most important information I should know about ibuprofen and oxycodone (Combunox)?
• What should I discuss with my healthcare provider before taking ibuprofen and oxycodone (Combunox)?
• How should I take ibuprofen and oxycodone (Combunox)?
• What happens if I miss a dose (Combunox)?
• What happens if I overdose (Combunox)?
• What should I avoid while taking ibuprofen and oxycodone (Combunox)?
• What other drugs will affect ibuprofen and oxycodone (Combunox)?
• Where can I get more information?

What happens if I miss a dose (Combunox)?

Since ibuprofen and oxycodone is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose (Combunox)?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of ibuprofen and oxycodone can be fatal.

Overdose symptoms may include extreme drowsiness, pinpoint pupils, nausea, vomiting, dark urine, jaundice (yellowing of the skin or eyes), black or bloody stools, coughing up blood, urinating less than usual or not at all, confusion, ringing in your ears, fainting, weak pulse, slow heart rate, coma, blue lips, shallow breathing, or no breathing.

What should I avoid while taking ibuprofen and oxycodone (Combunox)?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain ibuprofen or similar medicines. Read the label of any other medicine you are using to see if it contains ibuprofen, ketoprofen, or naproxen.

Avoid drinking alcohol while taking ibuprofen and oxycodone. Alcohol can increase the risk of stomach bleeding caused by ibuprofen.

What other drugs will affect ibuprofen and oxycodone (Combunox)?

Before using this medication, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by ibuprofen and oxycodone.

Also tell your doctor if you are using any of the following drugs:

• an antidepressant such as amitriptyline (Elavil, Etrafon) or imipramine (Janimine, Tofranil);
• an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate);
• aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as diclofenac (Voltaren), etodolac (Lodine), indomethacin (Indocin), naproxen (Aleve, Naprosyn), and others;
• an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril (Accupril), and others;
• lithium (Eskalith, Lithobid);
• a bronchodilator (such as Atrovent, Spiriva), diuretics (water pills), steroid medicines, or blood thinners;
• methotrexate (Rheumatrex, Trexall);
• atropine (Donnatal), dimenhydrinate (Dramamine), or scopolamine (Transderm-Scop); or
• bowel or bladder medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin), tolterodine (Detrol) and others;

This list is not complete and there may be other drugs that can interact with ibuprofen and oxycodone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about ibuprofen and oxycodone.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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