May 29, 2017
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"Despite being at the front lines in the nation's battle against opioid addiction as the first to treat chronic pain, and opioid overuse, few primary care and family physicians use the one drug available to them to treat addiction, buprenorphine, "...



Combunox Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking ibuprofen and oxycodone (Combunox)?

You should not use this medication if you have severe or uncontrolled asthma, or a stomach condition called paralytic ileus. Do not use ibuprofen and oxycodone just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Oxycodone may be habit forming and should be used only by the person it was prescribed for. Never share this medication with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

Ibuprofen may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term.

This medicine may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking ibuprofen and oxycodone, especially in older adults.

Do not use this medication if you are allergic to oxycodone or ibuprofen (Advil, Motrin), or other NSAIDs such as aspirin, Aleve, Celebrex, Orudis, Indocin, Lodine, Voltaren, Toradol, Mobic, Relafen, Feldene, and others.

To make sure you can safely take ibuprofen and oxycodone, tell your doctor if you have any of these other conditions:

  • heart disease, congestive heart failure, high blood pressure, or a history of heart attack, stroke, or blood clot;
  • asthma or other breathing disorders;
  • liver or kidney disease;
  • a history of head injury or brain tumor;
  • epilepsy or other seizure disorder;
  • stomach or intestinal disorder, history of stomach ulcer or bleeding;
  • underactive thyroid, a pancreas disorder, or Addison's disease or other adrenal gland disorder;
  • curvature of the spine;
  • an enlarged prostate or problems with urination; or
  • mental illness or a history of drug or alcohol addiction.

FDA pregnancy category D. Oxycodone may cause breathing problems and addiction or withdrawal symptoms in a newborn if the mother takes the medication during pregnancy. Taking ibuprofen during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using ibuprofen and oxycodone.

Ibuprofen and oxycodone may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more sensitive to the effects of this medicine.

How should I take ibuprofen and oxycodone (Combunox)?

Take exactly as prescribed. Never take ibuprofen and oxycodone in larger amounts, or for longer than recommended by your doctor. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Drink 6 to 8 full glasses of water daily to help prevent constipation while you are taking ibuprofen and oxycodone. Ask your doctor about ways to increase the fiber in your diet. Do not use a stool softener (laxative) without first asking your doctor.

If you need surgery, tell the surgeon ahead of time that you are using ibuprofen and oxycodone.

Store at room temperature away from moisture and heat.

Keep track of the amount of medicine used from each new bottle. Ibuprofen and oxycodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side Effects Centers

Combunox - User Reviews

Combunox User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Combunox sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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