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Brand Names: Combunox

Generic Name: ibuprofen and oxycodone (Pronunciation: eye byoo PROE fen and ox i KOE done)

• What is ibuprofen and oxycodone (Combunox)?
• What are the possible side effects of ibuprofen and oxycodone (Combunox)?
• What is the most important information I should know about ibuprofen and oxycodone (Combunox)?
• What should I discuss with my healthcare provider before taking ibuprofen and oxycodone (Combunox)?
• How should I take ibuprofen and oxycodone (Combunox)?
• What happens if I miss a dose (Combunox)?
• What happens if I overdose (Combunox)?
• What should I avoid while taking ibuprofen and oxycodone (Combunox)?
• What other drugs will affect ibuprofen and oxycodone (Combunox)?
• Where can I get more information?

What is ibuprofen and oxycodone (Combunox)?

Oxycodone is in a group of drugs called narcotic pain relievers.

Ibuprofen is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.

The combination of ibuprofen and oxycodone is used short-term to relieve moderate to severe pain.

Ibuprofen and oxycodone may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of ibuprofen and oxycodone (Combunox)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
• black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee ground;
• swelling or rapid weight gain;
• shallow breathing, slow heartbeat;
• confusion, feeling light-headed, fainting;
• easy bruising or bleeding;
• nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• severe blistering, peeling, and red skin rash; or
• fever, headache, neck stiffness, chills, increased sensitivity to light, purple spots on the skin, and/or seizure (convulsions).

Less serious side effects include:

• headache, dizziness, drowsiness;
• mild nausea, vomiting, upset stomach, bloating, gas, constipation, diarrhea;
• blurred vision; or
• dry mouth.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about ibuprofen and oxycodone (Combunox)?

Ibuprofen can increase your risk of heart attack or stroke. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG). Seek emergency medical help if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

Ibuprofen can also increase your risk of serious effects on the stomach or intestines. These conditions can be fatal and can occur without warning at any time while you are taking ibuprofen. Call your doctor at once if you have black, bloody, or tarry stools, or if you cough up blood or vomit that looks like coffee grounds.

Oxycodone may be habit-forming and should be used only by the person this medicine was prescribed for. Keep the medication in a secure place where others cannot get to it.

Avoid drinking alcohol while taking ibuprofen and oxycodone. Alcohol may increase your risk of stomach bleeding while taking ibuprofen.

Tell your doctor if the medicine seems to stop working as well in relieving your pain.