Compro (Prochlorperazine Suppositories) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

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Compro

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COMPRO™
(prochlorperazine) Suppositories, USP 25mg

ANTIEMETIC-TRANQUILIZER

DRUG DESCRIPTION

Prochlorperazine is a clear, pale yellow, viscous liquid. It is sensitive to light, very slightly soluble in water, freely soluble in alcohol, in chloroform, and in ether.

Each suppository, for rectal administration, contains 25mg of prochlorperazine; with glycerin, glyceryl monopalmitate, glyceryl monostearate, hydrogenated coconut oil fatty acids and hydrogenated palm kernel oil fatty acids.

Prochlorperazine has the molecular formula C₂₀H₂₄ClN₃S. Its molecular weight is 373.95. The chemical name for prochlorperazine is 2-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl] phenothiazine.

What are the possible side effects of rectal prochlorperazine (Compro)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using prochlorperazine and call your doctor at once if you have a serious side effect such as:

twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;
high fever, stiff muscles, confusion, sweating, fast...

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What are the precautions when taking prochlorperazine suppositories (Compro)?

Before using prochlorperazine, tell your doctor or pharmacist if you are allergic to it; or to other phenothiazines (e.g., chlorpromazine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used to treat patients who are unconscious or taking large amounts of any drug that causes drowsiness and slow/shallow breathing (e.g., alcohol, barbiturates, narcotics).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood disorders (e.g., bone marrow depression), ongoing breathing problems (e.g., asthma, emphysema), certain heart rhythm problems (e.g., prolonged QTc interval,...

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Last reviewed on RxList: 8/13/2008
This monograph has been modified to include the generic and brand name in many instances.