Comtan (Entacapone) Drug Center: Guide to Drug Information for Professionals, Patients and Caregivers at RxList

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May 26, 2012

Comtan

Parkinson's Disease »

What is Parkinson's disease?

Parkinson's disease is the second most common neurodegenerative disorder and the most common movement disorder. It is characterized by progressive loss of muscle control, which leads to trembling of the limbs and head while at rest, stiffness, slowness, and impaired balance. As symptoms worsen, it may become difficult to walk, talk, and complete simple tasks.

The progression of Parkinson's disease and the degree of impairment vary from individual to individual. Many people with Parkinson's disease live long productive lives, whereas others become disabled much more quickly. Premature death is usually due to complications such as falling-related injuries or pneumonia.

In the United States, about 1 million people are affected by Parkinson's disease and worldwide about 5 million. Most individuals who develop Parkinson's disease are 60 years of age or older. Parkinson's disease occurs in approximately 1% of i...

Read the Parkinson's Disease article »

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Comtan Drug Center

Medical Editor: John P. Cunha, DO, FACOEP

Prescribing Information

For Patients

Comtan (entacapone) is used together with carbidopa and levodopa to treat "wearing-off" symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control. It belongs to a class of drugs known as COMT inhibitors. Common side effects include nausea, vomiting, diarrhea, unwanted/uncontrolled movements, increased sweating, drowsiness, tiredness, dry mouth, gas, and abdominal pain.

The recommended dose of Comtan is one 200 mg tablet taken together with each levodopa/carbidopa dose to a maximum of 8 times daily (200 mg x 8 = 1600 mg per day). Comtan may interact with apomorphine, bitolterol, cholestyramine, dobutamine, epinephrine, isoetharine, isoproterenol, methyldopa, probenecid, or antibiotics. Tell your doctor all medications you are taking. During pregnancy, Comtan should be used only when prescribed. It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Our Comtan (entacapone) Drug Center provides a comprehensive view of available drug information as well as related drugs, user reviews, supplements, and diseases and conditions articles.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Comtan Prescribing Information: Indications & Dosage

COMTAN®
(entacapone) Structural Formula Illustration

Comtan (entacapone) is indicated as an adjunct to levodopa/carbidopa to treat patients with idiopathic Parkinson's Disease who experience the signs and symptoms of end-of-dose “wearing-off” (see CLINICAL PHARMACOLOGY, Clinical Studies).

Comtan (entacapone) 's effectiveness has not been systematically evaluated in patients with idiopathic Parkinson's Disease who do not experience end-of-dose “wearing-off”.

Read the complete drug monograph for Comtan »

What is Comtan Prescribing Information?

Drug Description - Indications & Dosage - Side Effects & Drug Interactions - Warnings & Precautions - Contraindications - Medication Guide and More

What is Patient information?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Comtan Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

feeling like you might pass out;
fever, stiff muscles, confusion, and sweating (especially when you first start taking entacapone);
hallucinations;
tremors (uncontrolled shaking);
tight feeling in your chest, trouble breathing;
severe or ongoing diarrhea; or
muscle pa...

Read the complete patient information for Comtan »

What is Comtan Patient Information?

Possible Side Effects - Images - What Is - How Should I Take It - What If I Miss a Dose - What Should I Avoid and More

What is Consumer information?

A concise overview of the drug for the patient or caregiver from First DataBank.

Comtan Consumer Information: Uses

This medication is used with other medications (levodopa/carbidopa) to treat Parkinson's disease. Entacapone belongs to a class of drugs known as COMT inhibitors. Many people taking levodopa for Parkinson's have problems with the effects of the levodopa wearing off between scheduled doses, causing symptoms to return or worsen. Entacapone blocks a certain natural substance (COMT enzyme) that breaks down the levodopa in the body. This effect allows the levodopa to last longer in the system so that it doesn't wear off before the next dose.

HOW TO USE: ...

Read the complete consumer information for Comtan »