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Comtan

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Comtan

COMTAN®
(entacapone) Tablets

DRUG DESCRIPTION

Comtan® (entacapone) is available as tablets containing 200 mg entacapone.

Entacapone is an inhibitor of catechol-O-methyltransferase (COMT), used in the treatment of Parkinson's disease as an adjunct to levodopa and carbidopa therapy. It is a nitrocatechol-structured compound with a relative molecular mass of 305.29. The chemical name of entacapone is (E)-2-cyano3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide. Its empirical formula is C14H15N3O5 and its structural formula is:

COMTAN® (entacapone) Structural Formula Illustration

The inactive ingredients of the Comtan tablet are microcrystalline cellulose, mannitol, croscarmellose sodium, hydrogenated vegetable oil, hydroxypropyl methylcellulose, polysorbate 80, glycerol 85%, sucrose, magnesium stearate, yellow iron oxide, red iron oxide, and titanium dioxide.

What are the possible side effects of entacapone (Comtan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • nausea, sweating, feeling like you might pass out;
  • fever, stiff muscles, confusion, and sweating (especially when you first start taking entacapone);
  • new or worsening cough, fever, trouble breathing;
  • hallucinations;
  • severe or ongoing diarrhea, extreme thirst, increased urination, weight loss, leg discomfort, muscle...

Read All Potential Side Effects and See Pictures of Comtan »

What are the precautions when taking entacapone (Comtan)?

Before taking entacapone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: alcoholism, liver problems, low blood pressure.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.

Older adults may be more sensitive to the side effects of this drug, especially drowsiness and confusion.

During pregnancy, this medication should be used only...

Read All Potential Precautions of Comtan »

Last reviewed on RxList: 6/27/2014
This monograph has been modified to include the generic and brand name in many instances.

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Comtan - User Reviews

Comtan User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Comtan sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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