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Signs And Symptoms
Signs and symptoms of CONCERTAR® overdosage, resulting principally from overstimulation of the CNS and from excessive sympathomimetic effects, may include the following: vomiting, agitation, muscle twitching, convulsion, grand mal convulsion, confusional state, hallucinations (auditory and/or visual), hyperhidrosis, headache, pyrexia, tachycardia, palpitations, heart rate increased, sinus arrhythmia, hypertension, rhabdomyolysis, mydriasis, and dry mouth.
Treatment consists of appropriate supportive measures. The patient must be protected against self-injury and against external stimuli that would aggravate overstimulation already present. Gastric contents may be evacuated by gastric lavage as indicated. Before performing gastric lavage, control agitation and seizures if present and protect the airway. Other measures to detoxify the gut include administration of activated charcoal and a cathartic. Intensive care must be provided to maintain adequate circulation and respiratory exchange; external cooling procedures may be required for pyrexia.
The prolonged release of methylphenidate from CONCERTAR® should be considered when treating patients with overdose.
Poison Control Center
As with the management of all overdosage, the possibility of multiple-drug ingestion should be considered. The physician may wish to consider contacting a poison control center for up-to-date information on the management of overdosage with methylphenidate.
Hypersensitivity To Methylphenidate
Hypersensitivity reactions, such as angioedema and anaphylactic reactions, have been observed in patients treated with CONCERTAR®. Therefore, CONCERTAR® is contraindicated in patients known to be hypersensitive to methylphenidate or other components of the product [see ADVERSE REACTIONS].
CONCERTA® is contraindicated in patients with glaucoma.
Monoamine Oxidase Inhibitors
CONCERTA® is contraindicated during treatment with monoamine oxidase (MAO) inhibitors, and also within a minimum of 14 days following discontinuation of a MAO inhibitor (hypertensive crises may result) [see DRUG INTERACTIONS].This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 1/6/2016
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