Condylox Gel (Podofilox Gel) Drug Information: Clinical Pharmacology

Pill Identifier Search

May 26, 2012

Condylox

Sexually Transmitted Diseases in Women (STDs) »

What are sexually transmitted diseases (STDs)?

Sexually transmitted diseases (STDs) are infections that can be transferred from one person to another through any type of sexual contact. STDs are sometimes referred to as sexually transmitted infections (STIs) since they involve the transmission of a disease-causing organism from one person to another during sexual activity. It is important to realize that sexual contact includes more than just sexual intercourse (vaginal and anal). Sexual contact includes kissing, oral-genital contact, and the use of sexual "toys," such as vibrators. STDs probably have been around for thousands of years, but the most dangerous of these conditions, the acquired immunodeficiency syndrome (AIDS or HIV disease), has only been recognized since 1984.

Many STDs are treatable, but effective cures are lacking for others, such as HIV, HPV, and hepatitis B and hepatitis C. Even gonorrhea, once easily cured, has become...

Read the Sexually Transmitted Diseases in Women (STDs) article »

« Previous
1
2
3
4
5
6
7
8
9
10
11
12
13
Next »

Condylox Gel User Reviews >>

Condylox Gel

Sexually Transmitted Diseases (STDs) Slideshow Pictures

A Visual Guide to Erectile Dysfunction

Take the Quiz on STDs

font size

CLINICAL PHARMACOLOGY

Mechanism of Action

Treatment of anogenital warts with podofilox results in necrosis of visible wart tissue. The exact mechanism of action is unknown.

Pharmacokinetics

In systemic absorption studies in 52 patients, topical application of 0.05 ml_ of an ethanolic solution containing 0.5% podofilox to external genitalia did not result in detectable serum levels. Applications of 0.1 to 1.5 ml_ resulted in peak serum levels of 1 to 17 ng/mL one to two hours after application. The elimination half-life ranged from 1.0 to 4.5 hours. The drug was not found to accumulate after multiple treatments¹.

Clinical Studies

In the first multicenter clinical study in 326 patients with anogenital warts, Condylox Gel (podofilox gel) 0.5% and its vehicle were applied in a double-blind fashion to comparable patient groups. Of the 260 patients with efficacy data, 176 were treated with Condylox Gel (podofilox gel) 0.5%. Patients applied Condylox Gel (podofilox gel) 0.5% twice daily for three consecutive days followed by a 4 day "rest" period.

At the end of 4 weeks, 38.4% of the patients had complete clearing of the wart tissue when treated with Condylox Gel (podofilox gel) 0.5%.

In the second multicenter clinical trial in 108 evaluable patients with anogenital warts, Condylox (podofilox) Topical Solution 0.5% was compared with Condylox Gel (podofilox gel) 0.5% for efficacy. As in the first clinical trial, patients applied Condylox Gel (podofilox gel) 0.5% twice daily for three consecutive days followed by a four day "rest" period.

Similar clearance rates were observed. At the end of 4 weeks, 25.6% of the patients had complete clearing of the wart tissue when treated with Condylox Gel (podofilox gel) 0.5%.

REFERENCES

1. von Krogh G. Podophyllotoxin in serum: Absorption subsequent to three day repeated applications of a 0.5% ethanolic preparation on condylomata acuminata. Sex Trans Disease 1982: 9: 26-33.

Last reviewed on RxList: 11/24/2008
This monograph has been modified to include the generic and brand name in many instances.