"In a press conference held today, top officials from CDC and the American Academy of Pediatrics announced that HPV vaccination rates in girls aged 13-17 years failed to increase between 2011 and 2012, according to data from the Centers for Diseas"...
Mechanism of Action
Treatment of genital warts with podofilox results in necrosis of visible wart tissue. The exact mechanism of action is unknown.
In systemic absorption studies in 52 patients, topical application of 0.05 mL of 0.5% podofilox solution to external genitalia did not result in detectable serum levels. Applications of 0.1 to 1.5 mL resulted in peak serum levels of 1 to 17 ng/mL one to two hours after application. The elimination half-life ranged from 1.0 to 4.5 hours. The drug was not found to accumulate after multiple treatments.
In clinical studies with Condylox Solution, the test product and its vehicle were applied in a doubleblind fashion to comparable patient groups. Patients were treated for two to four weeks, and reevaluated at a two-week follow-up examination. Although the number of patients and warts evaluated at each time period varied, the results among investigators were relatively consistent.
The following table represents the responses noted in terms of frequency of response by lesions treated and the overall response by patients. Data are presented for the 2-week follow-up only for those patients evaluated at that time point.
Responses in Treated Patients
|Responses in Treated Patients|
|Initially Cleared*||Recurred after Clearing*||Cleared at 2-Week Follow-up*|
|% Warts (n=524)||79% (412/524)||35% (146/412)||60% (269/449)|
|% Patients (n=70)||50% (35/70)||60% (21/35)||25% (14/57)|
|* Cleared and clearing mean no visible wart tissue remained at the treated Sites|
Last reviewed on RxList: 9/23/2015
This monograph has been modified to include the generic and brand name in many instances.
Additional Condylox Topical Information
Podofilox Topical Solution - User Reviews
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Find out what women really need.