In clinical trials, the following local adverse reactions were reported at some point during treatment.
| Adverse Experience |
Males |
Females |
| Burning |
64% |
78% |
| Pain |
50% |
72% |
| Inflammation |
71% |
63% |
| Erosion |
67% |
67% |
| Itching |
50% |
65% |
Reports of burning and pain were more frequent and of greater severity in women than in men.
Adverse effects reported in less than 5% of the patients included pain with intercourse, insomnia, tingling, bleeding, tenderness, chafing, malodor, dizziness, scarring, vesicle formation, crusting edema, dryness/peeling, foreskin irretraction, hematuria, vomiting and ulceration.