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Acetaminophen

Medical and Pharmacy Editor:

Brand Name: Tylenol, Tylenol Arthritis Pain, Tylenol Ext, Little Fevers Children's Fever/Pain Reliever, Little Fevers Infant Fever/Pain Reliever, PediaCare Single Dose Acetaminophen Fever Reducer/Pain Reliever

Generic Name: acetaminophen

Drug Class: Analgesics, Other

What Is Acetaminophen and How Does It Work?

Acetaminophen is an analgesic used to temporarily relieve minor aches and pains due to headache, muscular aches, backache, minor pain of arthritis, the common cold, toothache, and premenstrual and menstrual cramps. Acetaminophen is also used to temporarily reduce fever.

Acetaminophen is available under the following different brand names: Tylenol, Tylenol Arthritis Pain, Tylenol Ext, Little Fevers Children's Fever/Pain Reliever, Little Fevers Infant Fever/Pain Reliever, and PediaCare Single Dose Acetaminophen Fever Reducer/Pain Reliever.

Dosages of Acetaminophen Should Be Given As Follows:

Adult Dosage Forms & Strengths

Tablets

  • 325 mg
  • 500 mg

Caplets

  • 325 mg
  • 500 mg
  • 650 mg

Capsules

  • 500 mg

Gelcaps/Geltabs

  • 500 mg

Caplets, Extended Release

  • 650 mg

Tablets, Chewable

  • 80 mg

Oral solution/suspension

  • 160 mg/5 mL
  • 80mg/0.8mL (oral drops)

Liquid Oral

  • 500mg/5mL
  • 160mg/15mL
  • 500mg/15mL

Oral Syrup

  • 160mg/5mL

Elixir

  • 160mg/5mL

Dosage Considerations

Analgesia and Fever

Immediate release

  • Regular strength: 325-650 mg orally/rectally once every 4 hours as needed; not to exceed 3250 mg/day; under supervision of healthcare professional, daily doses of up to 4 g/day may be used
  • Extra Strength: 1000 mg orally once every 6-8 hours as needed; not to exceed 3000 mg/day; under supervision of healthcare professional, daily doses of up to 4 g/day may be used

Extended release

  • 2 capsules (1300 mg) orally once every 8 hours as needed; not to exceed 3.9 g/day

Maximum dose

  • Acetaminophen containing products: Not to exceed a cumulative dose of 3.25 g/day of acetaminophen; under supervision of healthcare professional, daily doses of up to 4 g/day may be used
  • Tylenol Extra-Strength (i.e., 500 mg/tab or cap): Not to exceed 3 g/day (6 tabs or caps); under supervision of healthcare professional, daily doses of up to 4 g/day may be used

Renal Impairment

Longer dosing intervals and reduced total dose may be warranted in patients with severe renal impairment (CrCl less than or equal to 30 mL/min)

Hepatic Impairment

Use with caution with any type of liver disease.

Pediatric Pain & Fever Relief

Weight-based dosing

  • Children under 12 years: 10-15 mg/kg/dose taken orally once every 4-6 hours; not to exceed 5 doses in 24 hours

Fixed dosing

  • Children under 6 years: Ask a healthcare provider
  • Children 6-12 years: 325 mg orally once every 4-6 hours; not to exceed 1.625 g/day for not more than 5 days unless directed by healthcare provider
  • Children under 12 years and older:
    • Regular strength: 650 mg once every 4-6 hours; not to exceed 3.25 g in 24 hours; under supervision of healthcare professional, doses of up to 4 g/day may be used
    • Extra strength: 1000 mg once every 6 hours; not to exceed 3 g in 24 hours; under supervision of healthcare professional, doses of up to 4 g/day may be used
    • Extended release: 1.3 g once every 8 hours; not to exceed 3.9 g in 24 hours
Medically Reviewed by a Doctor on 4/14/2017



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