May 25, 2017
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Adenosine

Medical and Pharmacy Editor:

Brand Name: Adenoscan, Adenocard

Generic Name: adenosine

Drug Class: Antidysrhythmics, V

What Is Adenosine and How Does It Work?

Adenosine is a prescription drug used for conversion to sinus rhythm of paroxysmal supraventricular tachycardia (PVST), including that associated with accessory bypass tracts (Wolff-Parkinson-White Syndrome). When clinically advisable, appropriate vagal maneuvers (Valsalva maneuver), should be attempted prior to adenosine administration.

Adenosine is available under the following different brand names: Adenocard, and Adenoscan.

Dosages of Adenosine:

Injectable solution

  • 3 mg/ml

Dosage Considerations – Should be Given as Follows:

Paroxysmal Supraventricular Tachycardia

Adult Dosage

  • Indicated for conversion to sinus rhythm of paroxysmal supraventricular tachycardia (PSVT), including that associated with accessory by pass tracts (Wolff-Parkinson-White Syndrome)
  • Adenocard: 6 mg intravenous push over 1-3 seconds (maybe given as intraosseous infusion) followed by rapid flush with 20 ml normal saline, if no conversion within 1-2 minutes give 12 mg intravenous pyelogram, repeat a second time if necessary (30 mg total)

Dosing considerations

  • When clinically advisable for paroxysmal supraventricular tachycardia (PSVT), appropriate vagal maneuvers (Valsalva maneuver), should be attempted prior to adenosine administration

Pediatric Dosage

  • Under 50 kg: 0.05 to 0.1 mg/kg rapid intravenous pyelogram over 1-3 seconds or intraosseous infusion, no more than 0.2 mg/kg/dose, followed by rapid flush with up to 5 ml 0.9% sodium chloride
  • If necessary may give second dose of 0.2 mg/kg intravenous pyelogram/intraosseous infusion, not to exceed cumulative dose of 12 mg

Geriatric Dosage

  • Elderly may experience more adverse effects from adenosine; they may be more sensitive
  • PSVT (Adenocard)
  • 6 mg intravenously (IV) over 1-3 seconds (maybe given by intraosseous infusion [IO]) followed by rapid flush with 20 ml normal saline (NS), if no conversion within 1-2 minutes give 12 mg IV, repeat a second time if necessary (30 mg total)
  • Adenoscan (Diagnostic)
  • Stress testing (Adenoscan): 140 mcg/kg/minute intravenous infusion for 6 minutes

Stress Testing (Diagnostic)

Other Indications and Uses

Medically Reviewed by a Doctor on 5/12/2017



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