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Allopurinol

Medical and Pharmacy Editor:

Brand Name: Zyloprim, Aloprim

Generic Name: allopurinol

Drug Class: Xanthine Oxidase Inhibitors; Antigout Agents

What Is Allopurinol and How Does It Work?

Allopurinol is a prescription medication used to treat gout and certain types of kidney stones. It is also used to prevent increased uric acid levels in patients receiving chemotherapy. These patients can have increased uric acid levels due to the release of uric acid from the dying cancer cells. Allopurinol works by reducing the amount of uric acid made by the body. Increased uric acid levels can cause gout and kidney problems.

Allopurinol is available under the following different brand names: Zyloprim and Aloprim.

Dosages of Allopurinol:

Adult and pediatric dosages:

Tablet

  • 100 mg
  • 300 mg

Powder for injection

  • 500 mg/vial

Dosage Considerations – Should be Given as Follows:

Gout

  • Adult dosage:
  • Mild: 100 mg per day orally initially, increased weekly to 200-300 mg per day
  • Moderate to severe: 100 mg per day orally initially, increased weekly to 400-600 mg per day

Excess of Uric Acid (Hyperuricemia)

  • Pediatric dosage:
  • 10 mg/kg per day orally divided every 12 hours, not to exceed 600 mg/day

Antineoplastic-Induced Excess of Uric Acid (Hyperuricemia)

  • Pediatric dosage:
  • 10 mg/kg per day orally divided every 12 hours, not to exceed 600 mg/day
  • Adult dosage:
  • 600-800 mg divided every 8-12 hours, starting 1-2 days before chemotherapy
  • Intravenously: 200-400 mg/m2 per day, not to exceed 600 mg/m2 per day, may administer as single infusion or in equally divided doses at 6, 8, and 12 hour intervals beginning 1-2 days before chemotherapy
  • Dosing considerations:
  • Minimum oral dosage: 100-200 mg/day
  • Maximum oral dosage: 800 mg/day
  • Dosing modifications:
  • Renal impairment:
    • Creatinine clearance 10-20 ml/min: 200 mg/day
    • Creatinine clearance 3-10 ml/min: 100 mg/day
    • Creatinine clearance less than 3 ml/min: 100 mg/day at extended intervals
  • Pediatric dosage:
  • Children under 6 years old: 150 mg orally daily divided every 8 hours
  • Children 6-10 years old: 300 mg orally daily in a single dose or divided every 8 hours
  • Children 10 years and older: 600-800 mg orally daily, starting 1-2 days before chemotherapy
  • Intravenously: 200 mg/m2 per day initially, starting 1-2 days before chemotherapy
Medically Reviewed by a Doctor on 4/20/2017



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