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Calcitriol

Medical and Pharmacy Editor:

Brand Name: Calcijex, Rocaltrol

Generic Name: Calcitriol

Drug Class: Vitamin D Analogs

What Is Calcitriol and How Does It Work?

Calcitriol is a synthetic version of Vitamin D3 used to treat calcium deficiency with hypoparathyroidism (decreased functioning of the parathyroid glands) and metabolic bone disease in people with chronic kidney failure.

Calcitriol is available under the following different brand names: Calcijex and Rocaltrol.

Dosages of Calcitriol:

Adult and Pediatric Dosage Forms and Strengths

Capsule

  • 0.25 mcg
  • 0.5 mcg

Oral solution

  • 1 mcg/mL

Injectable solution

  • 1 mcg/mL

Dosage Considerations – Should be Given as Follows:

Chronic Renal Dialysis Associated Hypocalcemia

Oral

  • Adult, Initial: 0.25 mcg orally once/day to every other day; titrate by 0.5-1 mcg/day every 4-8 weeks
  • Pediatric: 0.25-2 mcg/day orally once/day

Intravenous (IV)

  • Initial: 1-2 mcg IV (0.02 mcg/kg) 3 times/week; adjust dose every 2-4 weeks
  • Maintenance: 0.5-4 mcg IV 3 times/week

Hypoparathyroidism/Pseudohypoparathyroidism

  • Adult, Initial: 0.25 mcg orally once/day; titrate by 0.25 mcg every 2-4 weeks
  • Adult, Maintenance: 0.5-2 mcg orally once/day
  • Children under 1 year: 0.04-0.08 mcg/kg orally once/day
  • Children 1-5 years: 0.25-0.75 mcg orally once/day
  • Children over 6 years: 0.5-2 mcg orally once/day

Secondary Hyperparathyroidism in Moderate to Severe Kidney Disease

  • Adult: 0.25 mcg/day orally; may increase to 0.5 mcg/day
  • Children under 3 years: 0.01-0.015 mcg/kg/day
  • Children 3 years and older: 0.25 mcg/day orally; may increase to 0.5 mcg/day

Familial Hypophosphatemia, Pediatric

  • Initial: 0.015-0.02 mcg/kg orally once/day
  • Maintenance: 0.03-0.06 mcg/kg orally once/day
  • No more than 2 mcg orally once/day

Hypocalcemia in Premature Infants

  • 1 mcg once/day orally for 5 days

Vitamin D Dependent Rickets (Off-label)

  • Adult: 1 mcg orally once/day
  • Pediatric: 0.5 mg orally twice daily; adjust dose to maintain normal serum calcium and parathyroid hormone (PTH) levels; after 2 years, median dose is 0.25 mcg/day

Hypocalcemic Tetany in Premature Infants (Off-label)

  • 0.05 mcg/kg intravenously (IV) once/day for 5-12 days

Administration

  • Goal is to maintain serum Ca 9-10 mg/dL
Medically Reviewed by a Doctor on 8/15/2017



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