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Celebrex (celecoxib)

Medical and Pharmacy Editor:

Brand Name: Celebrex

Generic Name: Celecoxib

Drug Class: NSAIDs

What Is Celecoxib and How Does It Work?

Celecoxib is a prescription nonsteroidal anti-inflammatory drug used for the relief of pain, fever, swelling and tenderness caused by arthritis. Celecoxib is also used for familial Familial Adenomatous Polyposis (FAP).

Celecoxib is available under the following different brand names: Celebrex.

Dosages of Celecoxib:

Adults and Pediatric Dosages

Capsule

  • 50 mg
  • 100 mg
  • 200 mg
  • 400 mg

Dosage Considerations – Should be Given as Follows:

Acute Pain and Primary Dysmenorrhea

  • 400 mg orally initially, then 200 mg as needed on the first day; 200 mg every 12 hours as needed on subsequent days

Ankylosing Spondylitis

  • 200 mg orally once daily or divided every 12 hours; if no effect after 6 weeks, may increase to 400 mg/day; if no adequate response observed after 6 weeks of taking 400 mg/day consider discontinuing therapy

Osteoarthritis

  • 200 mg orally once daily or divided every 12 hours

Rheumatoid Arthritis

  • 100-200 mg orally every 12 hours

Juvenile Rheumatoid Arthritis

  • Children under 2 years: safety and efficacy not established
  • Children 2 years and 10-25 kg: 50 mg orally every 12 hours
  • Children 2 years and over 25 kg: 100 mg orally every 12 hours
  • Consider alternative management in patients who are poor CYP2C9 metabolizers

Familial Adenomatous Polyposis (off-label)

  • 400 mg orally every 12 hours, taken with food
  • Usual medical care should be continued during celecoxib therapy

Dosage Modifications

Adult:

  • Liver (hepatic) impairment:
  • Moderate (child-pugh class B): decrease dose by 50%
  • Severe (child-pugh class C): Not recommended
  • Kidney (renal) impairment:

Pediatric:

  • Poor CYP2C9 Metabolizers
  • May consider reducing the initial dose by 50%; consider alternative therapy in patients that are poor CYP2C9 metabolizers
Medically Reviewed by a Doctor on 5/16/2017



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