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Chlorthalidone

Medical and Pharmacy Editor:

Brand Name: Hygroton, Thalitone, Chlorthalid

Generic Name: Chlorthalidone

Drug Class:Diuretics, Thiazide

What Is Chlorthalidone and How Does It Work?

Chlorthalidone is a prescription drug used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It is also used to reduce extra salt and water in the body caused by conditions such as heart failure, liver disease, and kidney disease. Decreasing extra salt and water in the body helps to decrease swelling (edema) and breathing problems caused by fluid in the lungs. Chlorthalidone is a "water pill" (diuretic). It increases the amount of urine you make, especially when you first start the medication. It also helps to relax the blood vessels so that blood can flow more easily.

Chlorthalidone is available under the following different brand names: Hygroton, Thalitone, and Chlorthalid.

Dosages of Chlorthalidone:

Tablet

  • 15 mg
  • 25 mg
  • 50 mg
  • 100 mg

Dosage Considerations – Should be Given as Follows:

Hypertension

Adult and Geriatric:

  • 25-100 mg/day orally; usual range, 12.5-25 mg/day

Pediatric (off-label):

  • 0.3 mg/kg/day orally initially, may be increased to 2 mg/kg/day; not to exceed 50 mg per day

Edema

Adult and Geriatric:

  • 50-100 mg/day orally or 100 mg orally every other day; not to exceed 200 mg/day

Diuresis

Geriatric:

  • 12.5-25 mg/day orally or 12.5-25 mg orally every other day; dosages greater than 25 mg/day offer only minimal advantage

Dosing Considerations

Administered in the morning with food

Overdose management

  • Normal saline may be used for volume replacement
  • Dopamine or norepinephrine may be used to treat hypotension
  • If dysrhythmia due to decreased potassium or magnesium is suspected, replace aggressively
  • If no symptoms are noted after 6 hours, discontinue treatment

Dosing Modifications

Renal impairment

  • Creatinine clearance under 10 ml/min: ineffective, do not use
  • Creatinine clearance over 10 ml/min: dose adjustment not necessary

Geriatric:

Medically Reviewed by a Doctor on 5/18/2017



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