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Diclofenac

Medical and Pharmacy Editor:

Brand Name: Cataflam, Voltaren-XR, Dyloject, Cambia, Zipsor, Zorvolex

Generic Name: diclofenac

Drug Class: NSAIDs

What Is Diclofenac and How Does It Work?

Diclofenac is indicated for treatment of primary dysmenorrhea, for relief of mild to moderate pain, for relief of the signs and symptoms of osteoarthritis, for relief of the signs and symptoms of rheumatoid arthritis, for relief of symptoms of ankylosing spondylitis and for relief of acute migraine symptoms.

Diclofenac has analgesic, anti-inflammatory, and antipyretic properties.

Diclofenac is available under the following different brand names: Cataflam, Voltaren-XR, Dyloject, Cambia, Zipsor, and Zorvolex.

Dosages of Diclofenac:

Adult and Pediatric Dosage Forms & Strengths

Tablet as potassium

  • 50 mg

Tablet delayed release as sodium

  • 25 mg
  • 50 mg
  • 75 mg

Tablet, extended-release

  • 100 mg

Capsule (Adult Only)

  • 18 mg
  • 25 mg
  • 35 mg

Powder packet for oral solution

  • 50 mg

Solution for IV injection (Adult Only)

  • 37.5mg/mL (Dyloject)

Dosage Considerations – Should be Given as Follows:

Rheumatoid Arthritis

Diclofenac potassium:

  • 50 mg orally every 8-12 hours
  • Diclofenac sodium: 50 mg orally every 8 hours or 75 mg orally every 12 hours
  • Extended release: 100 mg orally once daily; may be increased to 100 mg orally every 12 hours

Osteoarthritis

  • Diclofenac potassium: 50 mg orally every 8-12 hours
  • Diclofenac sodium: 50 mg orally every 8 hours or 75 mg orally every 12 hours
  • Extended release: 100 mg orally once daily; may be increased to 100 mg orally every 12 hours
  • Zorvolex: 35 mg orally three times/day

Juvenile Idiopathic arthritis (Off-label)

  • Safety and efficacy not established; drug has been used safely in limited number of children aged 3-16 years with juvenile rheumatoid arthritis
  • Children younger than 3 years: Safety and efficacy not established
  • Children 3 years and older: 2-3 mg/kg/day for up to 4 weeks

Ankylosing Spondylitis

  • Diclofenac sodium: 25 mg orally 4 or 5 times daily
  • Diclofenac potassium: 50 mg orally every 12 hours

Dysmenorrhea

  • Immediate-release (Cataflam): 100 mg orally once, then 50 mg orally every 8 hours as needed

Mild-to-Moderate Acute Pain

  • Immediate-release tab (Cataflam): 100 mg orally once, then 50 mg orally every 8 hours as needed
  • Zipsor: 25 mg orally four times/day as needed
  • Zorvolex: 18 mg or 35 mg orally three times/day

Pain (IV Administration)

  • Indicated for management of mild-to-moderate pain and moderate-to-severe pain alone or in combination with opioid analgesics
  • Use for the shortest duration consistent with individual patient treatment goals
  • 37.5 mg intravenous (IV) bolus injection infused over 15 seconds every 6 hours as needed, not to exceed 150 mg/day
  • To reduce the risk of renal adverse reactions, patients must be well hydrated prior to IV administration

Acute Migraine

  • Oral solution: 50 mg (1 packet) in 30-60 mL of water, mixed well and drunk immediately
  • Not for prophylaxis

Dosing Considerations

  • Diclofenac potassium: Cambia, Cataflam, Zipsor
  • Diclofenac sodium: Voltaren XR

Administration

  • Take with food or 8-12 oz of water to avoid GI adverse effects
  • Zorvolex: Take on empty stomach; food decreases AUC by 11% and peak concentration by 60%
  • Oral solution: Do not use liquids other than water to reconstitute; foods decrease effectiveness
  • May be combined with misoprostol
Medically Reviewed by a Doctor on 4/17/2017



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