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Doxazosin

Medical and Pharmacy Editor:

Brand Name: Cardura, Cardura XL, Doxadura

Generic Name: doxazosin

Drug Class: BPH, Alpha Blockers

What Is Doxazosin and How Does It Work?

Doxazosin is a prescription drug indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes, including this drug.

Doxazosin is available under the following different brand names: Cardura, Cardura XL, and Doxadura.

Dosages of Doxazosin:

Adult and Pediatric Dosages Dosage Forms and Strengths

Tablets

  • 1 mg
  • 2 mg
  • 4 mg
  • 8 mg

Tablet, extended release (adult dosage only)

  • 4 mg
  • 8 mg

Dosage Considerations – Should be Given as Follows:

Hypertension

Adult Dosage:

  • Immediate release: 1-16 mg orally once daily in the morning or at night
  • Extended release: not indicated for hypertension

Geriatric Dosage:

  • Avoid use for hypertension; high risk of orthostatic hypotension (Beers criteria); if used, lower initial dosages and gradual adjustments are recommended
  • Immediate release: 0.5-16 mg orally once daily in the morning or at night
  • Extended release: not indicated for hypertension

Pediatric Dosage: (off-label)

  • Immediate release: 1-4 mg orally once daily in the morning or at night

Benign Prostatic Hyperplasia

Adult and Geriatric Dosage:

  • Immediate release: 1-8 mg/day orally
  • Extended release: 4 mg/day orally initially at breakfast; may be increased to no more than 8 mg/day orally

Dosing Modifications

  • Liver (hepatic) impairment: Use with caution in mild-to-moderate hepatic dysfunction; do not use in severe impairment

Dosing Considerations

  • Give first dose and increase at bedtime to avoid fainting
Medically Reviewed by a Doctor on 5/3/2017



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