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Estradiol

Medical and Pharmacy Editor:

Brand Name: Estrace, Vivelle-Dot, Delestrogen, DepoEstradiol, Divigel, Elestrin, Alora, Estrace Cream, Estraderm Transdermal, estradiol topical, Estradot, Estrasorb, Estrogel, Evamist, Femtrace, Menostar, Minivelle, Vivelle, Climara

Generic Name: estradiol

Drug Class: Estrogen Derivatives

What Is Estradiol and How Does It Work?

Estradiol is a female hormone (estrogen). It is used by women to help reduce vaginal symptoms of menopause (such as vaginal dryness/burning/itching). These symptoms are caused by the body making less estrogen. When treating only vaginal symptoms of menopause, products applied directly inside the vagina (such as this medication) should be used first. Estrogens that are taken by mouth, absorbed through the skin, or injected may have greater risks of side effects due to more estrogen being absorbed.

Estradiol is available under the following different brand names: Estrace, Vivelle-Dot, Delestrogen, DepoEstradiol, Divigel, Elestrin, Alora, Estrace Cream, Estraderm Transdermal, estradiol topical, Estradot, Estrasorb, Estrogel, Evamist, Femtrace, Menostar, Minivelle, Vivelle, and Climara.

Dosages of Estradiol:

Dosage Forms and Strengths

Gel

  • 0.06%
  • 0.1%

Injectable solution

  • 5 mg/mL
  • 10 mg/mL
  • 20 mg/mL
  • 40 mg/mL

Tablet

  • 0.45 mg (as acetate)
  • 0.5 mg
  • 0.9 mg (as acetate)
  • 1 mg
  • 1.5 mg
  • 2 mg

Transdermal patch

  • 0.0375 mg
  • 0.05 mg
  • 0.06 mg
  • 0.075 mg
  • 0.1 mg

Topical emulsion

  • 4.35 mg/1.74g (0.25%)

Dosage Considerations – Should be Given as Follows:

  • Pediatric: Safety and efficacy not established

Vulvar and Vaginal Atrophy in Menopause

  • Estrace: 1-2 mg orally once daily for 3 weeks, followed by 1 week off
  • Valerate: 10-20 mg intramuscularly (IM) every 4 weeks
  • EstroGel: 1.25 g/day 3 weeks on, 1 week off
  • Alora, Climara Vivelle-Dot, Estraderm: Use transdermally and follow product-specific directions
  • Prevention of osteoporosis: 0.5 mg orally once daily for 3 weeks, followed by 1 week off
  • Metastatic breast cancer: 10 mg orally every 8 hours for 3 months
  • Prostate cancer: 1-2 mg orally every 8 hours for 3 months or more

Hypoestrogenism from Castration, Hypogonadonism, or Ovarian Failure

  • Oral (Estrace): 1-2 mg orally once/day; titrate to use minimal effective dose
  • Transdermal (Alora, Estraderm, Climara, Vivelle-Dot, Minivelle): Use transdermally and follow product-specific directions
  • Valerate: 10-20 mg intramuscularly (IM) every 4 weeks

Hypoestrogenism

  • Cypionate: 1.5-2 mg intramuscularly (IM) every 4 weeks

Osteoporosis

  • Oral (Estrace): 0.5 mg/day for 23 days of 28-day cycle used in clinical studies
  • Transdermal (Alora, Menostar, Estraderm, Vivell-Dot, Minivelle): Follow product specific directions

Vasomotor Symptoms Associated with Menopause

  • Estrace: 1-2 mg/day 3 weeks on, 1 week off
  • Valerate: 10-20 mg intramuscularly (IM) every 3-4 weeks
  • Cypionate: 1-5 mg IM every 3-4 weeks
  • Estrasorb: 3.48 g of emulsion applied once/day in the morning
  • Elestrin: 0.87 g/day gel applied at the same time each day; use patient's response to adjust dose
  • Divigel: 0.25 g/day gel; adjust dose based on patient response
  • EstroGel: 1.25 g/day gel applied at the same time each day

Prostate Cancer

  • Estrace: 1-2 mg orally three times daily
  • Valerate: 30 mg intramuscularly (IM) or more every 1-2 weeks
Medically Reviewed by a Doctor on 4/18/2017



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