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Etodolac

Medical and Pharmacy Editor:

Brand Name: Lodine

Generic Name: Etodolac

Drug Class: NSAIDs

What Is Etodolac and How Does It Work?

Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis, rheumatoid arthritis, and acute pain.

Etodolac is available under the following different brand names: Lodine.

Dosages of Etodolac:

Dosage Forms and Strengths

Tablet (adult only)

  • 400 mg
  • 500 mg

Capsule (adult only)

  • 200 mg
  • 300 mg

Tablet, extended-release (adult and pediatric)

  • 400 mg
  • 500 mg
  • 600 mg

Dosage Considerations – Should be Given as Follows:

Pain

  • Immediate release: 200-400 mg orally every 6-8 hours; not to exceed 1000 mg/day (not evaluated)

Osteoarthritis

  • Immediate release: 600-1000 mg/day orally divided every 8-12 hours or 900 mg/day orally divided every 8 hours; doses greater than 1000 mg/day not evaluated
  • Extended release: 400-1000 mg orally once daily; not to exceed 1200 mg/day (not evaluated)

Rheumatoid Arthritis

  • Immediate release: 600-1000 mg/day orally divided every 8-12 hours or 900 mg/day orally divided every 8 hours; doses greater than 1000 mg/day not evaluated
  • Extended release: 400-1000 mg orally once daily; not to exceed 1200 mg/day (not evaluated)

Juvenile Rheumatoid Arthritis

Children under 6 years

  • Safety and efficacy not established

Children 6-16 years

  • 20-30 kg (extended release): 400 mg orally once daily
  • 31-45 kg (extended release): 600 mg orally once daily
  • 46-60 kg (extended release): 800 mg orally once daily
  • Over 60 kg (extended release): 1000 mg orally once daily

Dosing considerations

  • Safety and effectiveness of conventional tablets for juvenile rheumatoid arthritis not established

Dosing Considerations

  • Take with food or 8-12 oz of water to avoid gastrointestinal (GI) effects
  • Less than 60 kg: Not to exceed 20 mg/kg orally
  • Mild-to-moderate renal impairment: Dose adjustment not necessary
  • Severe renal impairment; Not recommended
  • Hepatic impairment: Dose adjustment not necessary
Medically Reviewed by a Doctor on 8/22/2017



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