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Glucagon

Medical and Pharmacy Editor:

Brand Name: Glucagen, Glucagon Emergency Kit, GlucaGen HypoKit

Generic Name: Glucagon

Drug Class: Hypoglycemia Antidotes; Diagnostics, Gastrointestinal; Glucose-Elevating Agents

What Is Glucagon and How Does It Work?

Glucagon is a prescription drug for injection is a gastrointestinal motility inhibitor indicated for use as a diagnostic aid during radiologic examinations to temporarily inhibit movement of the gastrointestinal (GI) tract.

Glucagon is available under the following different brand names: Glucagen, Glucagon Emergency Kit, and GlucaGen HypoKit.

Dosages of Glucagon:

Adult and Pediatric Dosages

Injection, powder

  • 1 mg/vial

Oral liquid

  • 55%

Dosage Considerations – Should be Given as Follows:

Hypoglycemia

Adults

  • Indicated for severe hypoglycemic reactions in patients with diabetes treated with insulin
  • 1 mg (1 unit) intramuscularly/subcutaneously/intravenously if no intravenous for glucagon
  • Repeat every 15 minutes once or twice; give glucagon as soon as it is available and if no response
  • Administer supplemental carbohydrate to replete glycogen stores

Pediatrics

  • Indicated for severe hypoglycemic reactions in patients with diabetes treated with insulin
  • Administer oral glucose/intravenous glucagon to replete glycogen stores
  • GlucaGen
    • Children under 6 years: 0.5 mg subcutaneous/intramuscular/intravenous; may repeat in 15 minutes if necessary
    • Children over 6 years: 1 mg subcutaneous/intramuscular/intravenous; may repeat in 15 minutes if necessary
    • Alternatively
      • Children under 25 kg: 0.5 mg; may repeat in 15 minutes if necessary
      • Children 25 kg or over: 1 mg; may repeat in 15 minutes if necessary
  • Infants over 6 months and children:
    • 0.5-1 g/kg up to 25 g (2-4 ml/kg/dose of 25% solution) intravenously; not to exceed 25 g/dose
  • Adolescents
    • Intravenously: 10-25 g (20-50 ml 50% solution or 40-100 ml of 25%)
    • Orally: 4-20 g as a single dose; may repeat after 15 minutes if self-monitoring of blood glucose shows continued hypoglycemia

Glucagon Emergency Kit

  • Children under 20 kg: 0.5 mg subcutaneous/intramuscular/intravenous every 15 minutes as needed, or 0.02-0.03 mg/kg/dose subcutaneous/intramuscular/intravenous; may repeat in 15 minutes if necessary
  • Children 20 kg or over: 1 mg subcutaneous/intramuscular/intravenous; may repeat in 15 minutes if necessary every 20 minutes as needed

Radiography of Gastrointestinal

  • Indicated as diagnostic aid for decreased gastrointestinal motility
  • To inhibit motility of stomach and small bowel: 0.2-0.5 mg intravenously over time period of 1 minute or 1 mg intramuscularly
  • To inhibit motility of colon: 0.5-0.75 mg intravenously over time period of 1 minute or 1 mg intramuscularly
  • Bolus doses over 1 mg administered intravenously may cause nausea and vomiting and are not recommended

Beta-Blocker and Calcium Channel Blocker Toxicity (off-label)

Medically Reviewed by a Doctor on 5/16/2017



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