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Lovastatin

Medical and Pharmacy Editor:

Brand Name: Mevacor, Altoprev

Generic Name: Lovastatin

Drug Class: Lipid-Lowering Agents, Statins; HMG-CoA Reductase Inhibitors

What Is Lovastatin and How Does It Work?

Lovastatin is a cholesterol-lowering medication called a statin prescribed to treat elevated blood cholesterol levels. Lovastatin should be used in addition to dietary modifications as part of a treatment plan to lower cholesterol levels when the response to diet and other non-pharmacological measures alone have been inadequate to reduce cardiovascular risk.

Lovastatin is available under the following different brand names: Mevacor, and Altoprev.

Dosages of Lovastatin:

Dosage Forms and Strengths

Tablets, extended-release

  • 10 mg
  • 20 mg
  • 40 mg
  • 60 mg

Tablets

  • 10 mg
  • 20 mg
  • 40 mg

Dosage Considerations – Should be Given as Follows:

Hypercholesterolemia

  • Mevacor (immediate-release): 20 mg orally once/day with evening meal initially, or may divide daily dose twice daily; adjust dose at 4-week intervals if increase required; not to exceed 80 mg/day
  • Altoprev (extended-release): 10-60 mg orally at bedtime

Heterozygous Familial Hypercholesterolemia, Pediatric

  • Children 10-17 years: 20-40 mg orally once/day; not to exceed 40 mg/day
  • Initiate with 10 mg/day if patient requires smaller LDL-C reduction

Dosing Considerations

Dosing Modifications

  • Renal impairment (severe; CrCl less than 30 mL/minute): Doses greater than 20 mg/day should be carefully considered and, if deemed necessary, implemented cautiously
Medically Reviewed by a Doctor on 8/9/2017



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