Memantine (cont.)

What Are Side Effects Associated with Using Memantine?

Side effects of memantine include:

• dizziness
• confusion
• headache
• constipation
• cough
• high blood pressure (hypertension)
• backache
• pain
• sleepiness
• fainting
• vomiting
• shortness of breath
• fatigue
• acute kidney failure
• blockage in the brain (cerebral infarction)
• stroke (cerebrovascular accident)
• deep venous thrombosis
• hepatitis, liver failure
• intracranial hemorrhage
• neuroleptic malignant syndrome ([NMS] fever, altered mental status, muscle rigidity and autonomic dysfunction)
• seizure (including grand mal)
• Stevens-Johnson syndrome
• disruption of blood supply to the brain or eye (transient ischemic attack, or mini-stroke)

Postmarketing side effects of memantine reported include:

• Blood and lymphatic system disorders: vulnerability to infection (agranulocytosis); reduced white blood cells (leukopenia, neutropenia); deficiency of red blood cells, white blood cells and platelets (pancytopenia); low platelets (thrombocytopenia); blood clots (thrombotic thrombocytopenic purpura [TTP])
• Cardiac disorders: cardiac failure congestive
• Gastrointestinal disorders: pancreatitis
• Hepatobiliary disorders: inflammation of the liver (hepatitis)
• Psychiatric disorders: suicidal ideation
• Renal and urinary disorders: Acute kidney failure (including increased creatinine and kidney insufficiency)
• Skin disorders: Stevens-Johnson syndrome

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.