Methotrexate (cont.)

What Other Drugs Interact with Methotrexate?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Severe interactions of methotrexate include:

• acitretin
• influenza virus vaccine quadrivalent, intranasal
• measles mumps and rubella vaccine, live
• measles, mumps, rubella and varicella vaccine, live
• poliovirus vaccine live oral trivalent
• rotavirus oral vaccine, live
• smallpox (vaccinia) vaccine, live
• typhoid vaccine live
• varicella virus vaccine live
• yellow fever vaccine
• zoster vaccine live

Methotrexate has serious interactions with at least 49 different drugs.

Methotrexate has moderate interactions with at least 109 different drugs.

Mild Interactions of methotrexate include:

• adalimumab
• colestipol
• folic acid
• golimumab
• hydrochlorothiazide
• l-methylfolate
• maitake
• methyclothiazide

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.