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Medical and Pharmacy Editor:

Brand Name: Simcor

Generic Name: niacin

Drug Class: Lipid-Lowering Agents, Statins; and HMG-CoA Reductase Inhibitors

What Is Niacin and How Does It Work?

Niacin is form of vitamin B3. Niacin is also called nicotinic acid. Niacin is not stored in the body which means that you need a regular supply of niacin through vitamins and foods. Niacin helps the digestive system, skin, and nerves to function. It is also important converting food to energy.

Niacin is a used as a treatment option for low cholesterol (HDL), high cholesterol (LDL), and triglyceride levels.

Niacin is available under the following different brand names: Simcor

Dosages of Niacin Should Be Given As Follows:


  • 50 mg - 1 gram tablet, extended release taken by mouth

Dosage Considerations

  • Take with cold liquid and a low-fat snack.
  • Swallow tablet whole; do not break, crush, or chew.
  • Flushing may be reduced by pre-treatment with no enteric-coated aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs), 30 minutes before dose.
  • Reiterate dose if therapy discontinued for over 7 days.
  • Due to risk of hepatotoxicity, substitute Simcor only for equivalent doses of niacin-ER, and no other forms of niacin.
  • Monitor liver function tests 6 weeks after initiation or dose escalation.

Adult Dosage


December 31, 2015: Manufacturer voluntarily withdrew drug from the market and discontinued distribution April 15, 2016: Based on several large cardiovascular outcome trials including AIM-HIGH, ACCORD, and HPS2-THRIVE, the FDA decided that "scientific evidence no longer supports the conclusion that a drug-induced reduction in triglyceride levels and/or increase in HDL-cholesterol levels in statin-treated patient's results in a reduction in the risk of cardiovascular events". Consistent with this conclusion, the FDA has determined that the benefits of niacin ER tablets for co-administration with statins no longer outweigh the risks, and the approval for this indication should be withdrawn.

Pediatric Dosage

Safety and efficacy has not been established.

Medically Reviewed by a Doctor on 3/8/2017

Cholesterol Management

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