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Pioglitazone

Medical and Pharmacy Editor:

Brand Name: Actos

Generic Name: Pioglitazone

Drug Class: Antidiabetics, Thiazolidinediones

What Is Pioglitazone and How Does It Work?

Pioglitazone is a prescription drug indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus in multiple clinical settings.

Pioglitazone exerts its antihyperglycemic effect only in the presence of endogenous insulin. Pioglitazone should not be used to treat type 1 diabetes or diabetic ketoacidosis, as it would not be effective in these settings.

Pioglitazone is available under the following different brand names: Actos.

Dosages of Pioglitazone:

Tablet

  • 15 mg
  • 30 mg
  • 45 mg

Dosage Considerations – Should be Given as Follows:

Type 2 Diabetes Mellitus

  • Indicated as monotherapy or with insulin or insulin secretagogues
  • 15-30 mg orally with meal every daily initially; may increase dose by 15 mg with careful monitoring to 45 mg each day
  • Monitor ALT at start of treatment, each month for 12 months, then every 3 months thereafter

Dosage Modification

  • Coadministration with insulin secretagogue (sulfonylurea): Decrease insulin secretagogue dose
  • Coadministration with insulin: Decrease insulin dose by 10-25%
  • Coadministration with strong CYP2C8 inhibitors (gemfibrozil): Limit maximum pioglitazone dose to 15 mg daily

Not recommended for pediatric use

Medically Reviewed by a Doctor on 5/18/2017



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