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Prasugrel

Medical and Pharmacy Editor:

Brand Name: Effient

Generic Name: Prasugrel

Drug Class: Antiplatelet Agents, Cardiovascular; Antiplatelet Agents, Hematologic

What Is Prasugrel and How Does It Work?

Prasugrel is an antiplatelet drug that prevents the platelets in the bloodstream from aggregating and forming blood clots, used to prevent blood clots in people with acute coronary syndrome who are undergoing a procedure after a recent heart attack or stroke, and in people with certain disorders of the heart or blood vessels.

Prasugrel is available under the following different brand names: Effient.

Dosages of Prasugrel:

Dosage Forms and Strengths

Tablet

  • 5 mg
  • 10 mg

Dosage Considerations – Should be Given as Follows:

Acute Coronary Syndrome

  • Reduction of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome (ACS) managed by means of percutaneous coronary intervention (PCI) who have either (a) unstable angina or non-ST-elevation MI (NSTEMI) or (b) ST-elevation MI (STEMI) when managed with primary or delayed PCI
  • 60 mg orally once as loading dose, then 10 mg/day orally in combination with aspirin 81-325 mg/day; if patient less than 60 kg, consider 5 mg/day orally because of potentially increased bleeding risk (efficacy and safety not established)
  • Geriatric, under 75 years:
    • 60 mg orally once as loading dose, then 10 mg/day orally in combination with aspirin 81-325 mg/day
    • Weight less than 60 kg: consider 5 mg/day because of potentially increased bleeding risk (efficacy and safety not established)
    • Geriatric, 75 years and older: Generally not recommended, because of increased risk of fatal and intracranial bleeding and uncertain benefit, except in high-risk patients (diabetes or prior heart attack [myocardial infarction]), for whom effect appears to be greater and use may be considered

Dosing Modifications

Renal impairment

  • Dose adjustment not necessary

Hepatic impairment

  • Mild-to-moderate: Dose adjustment not necessary
  • Severe: Not studied

Pediatric

  • Not recommended
Medically Reviewed by a Doctor on 9/6/2017



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