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Quinapril

Brand Name: Accupril

Generic Name: Quinapril

Drug Class: ACE Inhibitors

What Is Accupril and How Does It Work?

Quinapril is an angiotensin converting enzyme (ACE) inhibitor used for treating high blood pressure and heart failure.

Quinapril is available under the following different brand names: Accupril.

Dosages of Accupril:

Adult and Pediatric Dosage Forms and Strengths

Tablet

  • 5 mg
  • 10 mg
  • 20 mg
  • 40 mg

Dosage Considerations – Should be Given as Follows:

Hypertension

  • Adult, initial: 10-20 mg orally once/day; may administer 5 mg in patients receiving diuretic therapy if the diuretic is continued
  • Adult, maintenance: 20-80 mg orally once/day or divided every 12 hours
  • Pediatric, off-label: 5-10 mg orally once/day initially

Dosing Modifications

Renal impairment

  • Dose adjustment not necessary

Congestive Heart Failure

  • Initial: 5 mg orally every 12 hours
  • Maintenance: 20-40 mg orally once/day or divided every 12 hours

Diabetic Nephropathy (Off-Label)

  • Slows rate of progression of renal disease in patients with hypertension, diabetes mellitus, and microalbuminuria
  • Initial: 10-20 mg orally once/day
  • Maintenance: 20-80 mg orally once/day or divided every 12 hours

Dosage Modification

Renal impairment with hypertension

  • CrCl greater than 60 mL/minute: 10 mg/day
  • CrCl 30-60 mL/minute: 5 mg/day
  • CrCl 10-30 mL/minute: 2.5 mg/day
  • CrCl less than 10 mL/minute: Insufficient data

Renal impairment with congestive heart failure (CHF)

  • CrCl greater than 30 mL/minute: 5 mg/day
  • CrCl 10-30 mL/minute: 2.5 mg/day
  • CrCl less than 10 mL/minute: Insufficient data
  • Geriatric: 2.5-5 mg/day initially; increase dose by increments of 2.5-5 mg at 1-2 week intervals; adjust for renal impairment

    Medically Reviewed by a Doctor on 9/6/2017



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