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Sildenafil

Medical and Pharmacy Editor:

Brand Name: Revatio, Viagra

Generic Name: sildenafil

Drug Class: PAH, PDE-5 Inhibitors; Phosphodiesterase-5 Enzyme Inhibitors

What Is Silenafil and How Does It Work?

Sildenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, sildenafil works by increasing blood flow to the penis to help a man get and keep an erection.

Sildenafil does not protect against sexually transmitted diseases (such as HIV, hepatitis B, gonorrhea, syphilis). Practice "safe sex" such as using latex condoms. Consult your doctor or pharmacist for more details.

Sildenafil is also available in other brands and strengths for treating high blood pressure in the lungs (pulmonary hypertension). Do not take sildenafil with any other product that contains sildenafil or other similar medications for erectile dysfunction-ED or pulmonary hypertension (such as tadalafil, vardenafil).

Sildenafil is available under the following different brand names: Revatio, and Viagra.

Dosages of Sildenafil:

Dosage Forms and Strengths

Tablet (Revatio)

  • 20 mg

Tablet (Viagra)

  • 25 mg
  • 50 mg
  • 100 mg

Injectable solution (Revatio)

  • 10 mg/12.5mL

Oral suspension (Revatio)

  • 10 mg/12.5mL (when reconstituted)

Dosage Considerations – Should be Given as Follows:

Erectile Dysfunction

Viagra

  • 50 mg orally 1 hour before sexual activity
  • may be increased to 100 mg or reduced to 25 mg, depending on effectiveness and tolerance
  • not to exceed 100 mg/day

Pulmonary Arterial Hypertension

Revatio

  • Oral: 5 mg or 20 mg 3 times daily, administered 4-6 hours apart
  • Intravenous (IV): 2.5-mg or 10-mg bolus 3 times daily if patient is temporarily unable to take orally
  • Recommended oral/IV dose not to be exceeded
  • Adding Revatio to bosentan does not have any beneficial effect on exercise capacity

Dosing Modifications

  • Hepatic impairment or severe renal impairment: Use initial dose of 25 mg

Geriatric Dosing

Erectile Dysfunction

  • Viagra
  • Older than 65 years: 25 mg orally initially 1 hour before sexual activity

Pulmonary Arterial Hypertension

  • Revatio
  • Oral: 5 mg or 20 mg 3 times daily, administered 4-6 hours apart
  • Intravenous (IV): 2.5-mg or 10-mg bolus 3 times daily if patient is temporarily unable to take orally
  • Recommended oral/IV dose not to be exceeded
  • Adding Revatio to bosentan does not have any beneficial effect on exercise capacity
  • Clinical trials found no significant difference in response between elderly patients and younger adults; however, cautious dose selection should be considered in elderly because of greater frequency of decreased hepatic, renal, and cardiac function, as well as comorbid conditions and concomitant pharmacotherapy
  • Compared with healthy younger volunteers, healthy elderly volunteers (65 years and older) had reduced clearance of sildenafil, resulting in approximately 84% and 107% higher plasma concentrations of sildenafil and its active N-desmethyl metabolite, respectively

Pediatric

  • Not to be prescribed to children (1-17 years) for pulmonary arterial hypertension (PAH); this recommendation against use is based on long-term clinical pediatric trial showing that children taking high doses had higher risk of death than children taking low doses and that low doses were not effective in improving exercise ability
Medically Reviewed by a Doctor on 4/11/2017




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