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Sotalol

Medical and Pharmacy Editor:

Brand Name: Betapace, Betapace AF, Sorine, Sotylize

Generic Name: Sotalol

Drug Class: Antidysrhythmics, II; Antidysrhythmics, III; Beta-Blockers, Nonselective

What Is Sotalol and How Does It Work?

Sotalol is a prescription drug indicated for the treatment of life-threatening, documented ventricular arrhythmias, such as sustained ventricular tachycardia (VT).

Sotalol is available under the following different brand names: Betapace, Betapace AF, Sorine, and Sotylize.

Dosage of Sotalol:

Adult and Pediatric Dosages:

Tablet

  • 80 mg
  • 120 mg
  • 160 mg
  • 240 mg

Oral solution

  • 5 mg/ml

Injectable solution

  • 15 mg/ml

Dosing Considerations – Should be Given as Follows:

Ventricular and Supraventricular Arrhythmias

  • Betapace or Sorine: 80 mg orally every 12 hours initially; increased as needed to 120-160 mg every 12 hours (2-3 days between increments)
  • Intravenous (substitute for oral): 75 mg over 5 hour every 12 hours initially; adjusted if necessary (on basis of monitoring of clinical efficacy, quarterly interval, and adverse effects) every 3 days; not to exceed 150 mg every 12 hours

Supraventricular Tachycardia

Pediatric

  • Children under 2 years old: reduce dose; see manufacturer's package insert for details
  • Children 2 years and older: 30 mg/m2 orally every 8 hours initially; may be titrated up to 180 mg/m2/day orally

Refractory Life-Threatening Ventricular Arrhythmias

  • Betapace or Sorine: 80 mg orally every 12 hours initially; increased as needed to 120-160 mg every 12 hours (2-3 days between increments) to 160-320 mg/day divided every 8-12 hours; up to 480-640 mg/day may be required if benefits outweigh increased adverse effects

Atrial Fibrillation/Flutter

  • 75 mg intravenously over 5 hours every 12 hours initially; adjusted if necessary every 3 days; not to exceed 150 mg intravenously every 12 hours

Betapace AF: 80 mg orally every 12 hours; increased as needed to 120-160 mg every 12 hours

Dosing modification

  • Renal impairment in Atrial Fibrillation/Flutter (Betapace AF)
  • Creatinine Clearance greater than 60 ml/min: give every 12 hours
  • Creatinine Clearance of 40-60 ml/min: give once daily
  • Creatinine Clearance under 40 ml/min: contraindicated

Renal impairment in Ventricular Arrhythmia (Betapace, Sorine)

  • Creatinine Clearance greater than 60 ml/min: give every 12 hours
  • Creatinine Clearance of 30-59 ml/min: give once daily
  • Creatinine Clearance of 10-29 ml/min: give every 36-48 hours
  • Creatinine Clearance under 10 ml/min: individualize dosing
Medically Reviewed by a Doctor on 6/12/2017



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