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Tobramycin

Medical and Pharmacy Editor:

Brand Name: Nebcin Injection

Generic Name: Tobramycin

Drug Class: Aminoglycosides

What Is Tobramycin and How Does It Work?

Tobramycin is a prescription aminoglycoside antibiotic used as treatment against Gram-positive and Gram-negative bacteria.

Tobramycin is available under the following different brand names: Nebcin injection.

Dosage of Tobramycin:

Adult and Pediatric Dosages:

Injectable solution

  • 10 mg/ml
  • 40 mg/ml

Dosage Considerations – Should be Given as Follows:

Bacterial infections

  • 3-6 mg/kg/day intravenously/intramuscularly divided every 8 hours OR
  • 4-7 mg/kg/dose intravenously/intramuscularly each day

Renal Impairment

Adult

  • Creatinine Clearance over 60 mL/min: every 8 hours
  • Creatinine Clearance 40-60 mL/min: every 12 hours
  • Creatinine Clearance 20-40 mL/min: every 24 hours
  • Creatinine Clearance 10-20 mL/min: every 48 hours
  • Creatinine Clearance under 10 mL/min: ever 72 hours
  • Following dialysis in ESRD

Pediatric

  • Children under 5 years old: 2.5 mg/kg/dose intravenously/intramuscularly every 8 hours
  • Children 5 years and older: 2-2.5 mg/kg/dose intravenously/intramuscularly every 8 hours
  • Hemodialysis: 1.25-1.75 mg/kg/dose post dialysis

Monitor

Adult and pediatric:

  • Peak and trough concentrations, renal and auditory function
  • Life-threatening infection: 8-10 mcg/mL
  • Serious infection: 6-8 mcg/mL
  • Urinary Tract Infections: 4-6 mcg/mL
  • Synergy for infections caused by gram-positive organisms: 3-5 mcg/mL

Cystic Fibrosis

Pediatric

  • Intravenously/intramuscularly: 2.5-3.3 mg/kg every 6-8 hours

Neonates

  • Less than 30 weeks gestation
  • Infants less than 28 days old: 2.5 mg/kg intravenously/intramuscularly every day
  • Infants 28 days or older: 3 mg/kg intravenously/intramuscularly every day

30-36 week gestation

  • Infants less than 14 days old: 3 mg/kg intravenously/intramuscularly every day
  • Infants 14 days or older: 5 mg/kg/day intravenously/intramuscularly divided every 12 hours

Over 37 week gestation

  • Infants less than 7 days old: 5 mg/kg/day intravenously/intramuscularly divided every 12 hours
  • Infants 7 days or older: 7.5 mg/kg/day intravenously/intramuscularly divided every 8 hours

Other Indications and Uses

May have increased activity against resistant Gram negative

    Citrobacter Spp., E. coli, P. aeruginosa, Proteus Spp. (indole-positive and negative), Providencia Spp. (including Klebsiella-Enterobacter-Serratia), S. aureus (coagulase-positive and negative)
Medically Reviewed by a Doctor on 6/8/2017



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