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Tolterodine

Medical and Pharmacy Editor:

Brand Name: Detrol, Detrol LA

Generic Name: Tolterodine

Drug Class: Anticholinergics, Genitourinary

What Is Tolterodine and How Does It Work?

Tolterodine is prescribed for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.

Tolterodine is available under the following different brand names: Detrol, and Detrol LA.

Dosage Forms and Strengths

Tablet, immediate release

  • 1 mg
  • 2 mg

Capsule, extended release

  • 2 mg
  • 4 mg

Dosage Considerations – Should be Given as Follows:

Overactive Bladder, Urge Incontinence)

  • Immediate release: 2 mg orally every 12 hours
  • Extended release: 2-4 mg orally once daily

Renal impairment

  • CrCl 10-30 mL/minute: Not to exceed 1 mg orally every 12 hours (immediate release) or 2 mg orally once daily (extended release)
  • CrCl less than 10 mL/minute: Not recommended

Hepatic impairment

  • Mild to moderate (Child-Pugh class A or B): Not to exceed 1 mg orally every 12 hours (immediate release) or 2 mg orally once daily (extended release)
  • Severe (Child-Pugh class C): Not recommended

Strong CYP3A4 inhibitors

  • Not to exceed 1 mg orally every 12 hours (immediate release) or 2 mg orally once daily (extended release)

Not recommended for pediatric use

Medically Reviewed by a Doctor on 6/15/2017



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